CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM77
Family Name Integrin beta-1 and Integrin alpha-4 inhibitor (3S)-3-(3,4-dimethoxyphenyl)-3-[[2-[3-methoxypropyl-[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]acetyl]amino]propanoic acid family
No. of Seeds 5 No. of Other Members 61
Family Centroid CFAMM00306789 Functional Category Bioactive with Natural Product
Superfamily Genome polyprotein Inhibitor Azapeptide Derivative Superfamily
Class Class 954

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Substance-K receptor Ligand MEN-14933 Family 13 154
Multidrug resistance protein 1 and Multidrug resistance-associ... 3 55
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Endothelin B receptor and Endothelin-1 receptor ligand SureCN8... 6 4
C-C chemokine receptor type 3 ligand 1-(3-cyanophenyl)-3-[6-[[... 2 5
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 9 37
Survival motor neuron protein and Retinal dehydrogenase 1 inhi... 1 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 1
Substance-P receptor ligand (2S,4S)-1-N-(3-chlorophenyl)-2-N-[... 5 2
Neuropeptide S receptor and Survival motor neuron protein liga... 1 2
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Coagulation factor VII and Trypsin-1 inhibitor (2S)-2-[[(2R)-2... 2 5
Coagulation factor VII and Prothrombin inhibitor (S)-[(R)-2-(4... 2 8
Integrin beta-1 and Integrin alpha-4 inhibitor AGN-PC-02YIN5 f... 3 5
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[1-[2-[4-[(2... 2 8
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-075FY0 f... 1 0
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 22
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 12 13
Integrin alpha-4 inhibitor SureCN14558473 family 7 4
Neuropeptide Y receptor type 1 ligand SureCN8354018 family 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 7
Integrin beta-3 and Integrin alpha-V inhibitor (3R)-3-(1,3-ben... 5 0
Integrin beta-3 and Integrin alpha-V inhibitor SureCN7496449 f... 3 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 13
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 10 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 0
Coagulation factor VII and Prothrombin inhibitor AGN-PC-0752MU... 2 1
Coagulation factor VII and Prothrombin inhibitor AGN-PC-0752KC... 3 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075HBO ... 2 44
spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole... 32 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00306804 CHEMBL156875 Bioactive (3S)-3-(1,3-benzodioxol-5-yl)-3-[[(2S)-4-methyl-2-[[4-[(2-methylphenyl)carbamoylamino]phenyl]methylamino]pentanoyl]amino]propanoic acid
CFAMM00306784 CHEMBL327274 Bioactive (3S)-3-(4-methoxyphenyl)-3-[[2-[3-methoxypropyl-[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]acetyl]amino]propanoic acid
CFAMM00306789 CHEMBL316723 Bioactive (3S)-3-(3,4-dimethoxyphenyl)-3-[[2-[3-methoxypropyl-[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]acetyl]amino]propanoic acid
CFAMM00306823 CHEMBL98599 Bioactive (3S)-3-(3,4-dimethoxyphenyl)-3-[[2-[4-methoxybutyl-[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]acetyl]amino]propanoic acid
CFAMM00306768 CHEMBL101151 Bioactive (3S)-3-(1,3-benzodioxol-5-yl)-3-[[(2S)-4-methyl-2-[[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]pentanoyl]amino]propanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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