CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7708
Family Name Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-aminobutyric acid receptor subunit beta-3 ligand CHEMBL440558 family
No. of Seeds 5 No. of Other Members 1
Family Centroid CFAMM00168780 Functional Category Bioactive
Superfamily Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-aminobutyric acid receptor subunit gamma-2 Ligand TPA-023 Superfamily
Class Class 855

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Corticotropin-releasing factor receptor 1 Ligand GSK561679 Family 5 6
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Ibrutinib family 2 27
PF-02545920 family 16 140
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 37
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 4
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CC4... 20 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 10 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 4 2
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 3 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
Translocator protein inhibitor AGN-PC-080ILF family 9 3
Leukotriene B4 receptor 1 ligand AGN-PC-075N6M family 2 4
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 4
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 6
Neuropeptide Y receptor type 1 ligand CP-671906 family 10 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 6 0
Voltage-dependent calcium channel subunit alpha-2/delta-1 and ... 9 15
Corticotropin-releasing factor receptor 1 ligand CHEMBL1819076... 2 0
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Corticotropin-releasing factor receptor 1 ligand CHEMBL1830528... 1 0
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 9
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Estrogen receptor and Estrogen receptor beta ligand 4-[3-[4-(2... 1 0
Metabotropic glutamate receptor 2 ligand 8-chloro-3-(cycloprop... 6 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 12 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Substance-P receptor ligand (2S,3S)-N-[[2-methoxy-5-(tetrazol-... 2 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 2 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CCL... 3 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CCI... 3 0
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
Acyl-CoA desaturase 1 inhibitor Pyridazine, 3-[4-(2-ethylpheno... 4 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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