CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7715
Family Name Serine/threonine-protein kinase mTOR and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform inhibitor AGN-PC-0A9PSV family
No. of Seeds 1 No. of Other Members 2
Family Centroid CFAMM00382593 Functional Category Bioactive with Human Metabolite
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform and Prelamin-A/C Binder Superfamily 2
Class Class 3587

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Emedastine Family 5 115
Histamine H1 receptor Ligand Mizolastine Family 14 603
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
HCV NS4B protein Inhibitor Clemizole Family 2 43
Tryptase Inhibitor Babim Family 12 90
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... 2 12
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Farnesyl pyrophosphate synthase Inhibitor [2-(benzoimidazol-1-... 2 16
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Histamine H4 receptor ligand SureCN602132 family 1 8
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Vascular endothelial growth factor receptor 2 and Mitogen-acti... 2 2
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
Smoothened homolog and Sonic hedgehog protein inhibitor N-cycl... 3 2
Histamine H4 receptor and Histamine H3 receptor ligand (E)-[(3... 4 3
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
C-C chemokine receptor type 3 ligand 5-fluoro-1-[1-[3-(4-fluor... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00382593 CHEMBL1760154 Bioactive AGN-PC-0A9PSV

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27515 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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