CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM772
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and Serine/threonine-protein kinase mTOR inhibitor SureCN3229654 family
No. of Seeds 11 No. of Other Members 391
Family Centroid CFAMM00315419 Functional Category Bioactive with Natural Product
Superfamily Cysteinyl leukotriene receptor 1 and Beta-lactamase Binder Superfamily
Class Class 2015

Cousin Family NamesSeedsMembers
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
Vascular endothelial growth factor receptor 2 Ligand PF-003372... 1 4
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Oestrogen receptor and Estrogen receptor beta Ligand 2-naphtha... 4 51
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Platelet-derived growth factor receptor beta and Receptor-type... 1 2
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family 2 506
Renin Inhibitor CP-305202 Family 9 30
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 20 28
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Vascular endothelial growth factor receptor 2 ligand 7-(6-acet... 2 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 8 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family 1 30
Inosine-5'-monophosphate dehydrogenase 2 inhibitor 7-methoxy-2... 7 1
Glycylpeptide N-tetradecanoyltransferase 2 and Glycylpeptide N... 8 10
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 3 17
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Cholinesterase and Acetylcholinesterase inhibitor 5-hydroxy-7-... 5 19
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Serine/threonine-protein kinase pim-1 inhibitor (2Z)-6-methoxy... 1 5
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor 4-(benzyloxy... 1 10
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 4 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 3
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cysteinyl leukotriene receptor 1 ligand 4-oxo-7-[[3-(quinolin-... 4 17
Substance-P receptor ligand SureCN2139814 family 7 7
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 1 8
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
Sodium-dependent serotonin transporter inhibitor SureCN5477150... 4 1
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 1 4
Aromatase inhibitor (4-chlorophenyl)-(6-methoxy-1-benzofuran-2... 1 4
Smoothened homolog inhibitor N-[amino-[3-(1H-indol-2-yl)anilin... 1 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(6aR... 1 0
Histamine H1 receptor and Histamine H2 receptor ligand SureCN6... 1 3
Histamine H1 receptor and Histamine H2 receptor ligand SureCN5... 3 6
Reverse transcriptase/RNaseH inhibitor 3-[2-(1-benzofuran-2-yl... 1 1
ATP-binding cassette sub-family G member 2 inhibitor 5-[(4-bro... 1 1
Adenosine receptor A1 ligand 7-hydroxy-3-methyl-1-(3-nitrophen... 1 0
Integrase and Serine/threonine-protein kinase pim-1 inhibitor ... 3 0
ATP-dependent DNA helicase Q1 and Ras-related protein Rab-9A i... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00315470 CHEMBL1090115 Bioactive SureCN3211158
CFAMM00315633 CHEMBL1090505 Bioactive (2Z)-4,6-dihydroxy-2-[[1-[2-[4-(3-hydroxypropyl)piperazin-1-yl]ethyl]-5-methoxy-2-methylindol-3-yl]methylidene]-1-benzofuran-3-one
CFAMM00315309 CHEMBL1089653 Bioactive (2Z)-4,6-dihydroxy-2-[(5-methoxy-1,2-dimethylindol-3-yl)methylidene]-1-benzofuran-3-one
CFAMM00315564 CHEMBL1089823 Bioactive SureCN4331516
CFAMM00315530 CHEMBL1093449 Bioactive SureCN4329551
CFAMM00315677 CHEMBL1090478 Bioactive SureCN4324970
CFAMM00315536 CHEMBL1093445 Bioactive SureCN4322473
CFAMM00315408 CHEMBL1091855 Bioactive SureCN4321121
CFAMM00315435 CHEMBL1088835 Bioactive (2Z)-4,6-dihydroxy-2-[(5-methoxy-2-methyl-1H-indol-3-yl)methylidene]-1-benzofuran-3-one
CFAMM00315387 CHEMBL1092189 Bioactive SureCN4318481
CFAMM00315419 CHEMBL1090153 Bioactive SureCN3229654

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27515 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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