CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7721
Family Name Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethylpropyl)-1-[[3-(trifluoromethoxy)phenyl]methyl]indole-2-carboxamide family
No. of Seeds 17 No. of Other Members 4
Family Centroid CFAMM00382644 Functional Category Bioactive
Superfamily Histamine H3 receptor and D(3) dopamine receptor Binder Superfamily
Class Class 2433

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Coagulation factor X Inhibitor Apixaban Family 34 52
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Integrin beta-3 Inhibitor L-756568 Family 8 59
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Cannabinoid receptor 1 and 5-hydroxytryptamine receptor 1A lig... 2 12
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
Histamine H3 receptor ligand (4S)-7-bromo-4-methyl-8-(1-propan... 2 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family 1 30
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-0759OR family 4 7
Coagulation factor X and Prothrombin inhibitor 6-[4-[2-[[(3R)-... 15 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
NS5B protein inhibitor AC1O5AET family 3 1
Glucagon receptor ligand 3-[[4-[(2S)-2-[5-(trifluoromethoxy)-1... 1 2
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Vitamin D3 receptor ligand 1-ethyl-5-[3-[4-(2-hydroxy-3,3-dime... 2 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Coagulation factor X and Prothrombin inhibitor SureCN6434488 f... 3 13
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Vasopressin V2 receptor ligand SureCN4400636 family 1 0
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Histamine H3 receptor ligand SureCN1397929 family 1 1
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Potassium voltage-gated channel subfamily A member 5 ligand AG... 1 0
Pol polyprotein inhibitor Phenprocoumon IndolEtCONH deriv. family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00382637 CHEMBL1760662 Bioactive 5-cyano-N-(2-hydroxy-2-methylpropyl)-1-[[2-methoxy-5-(trifluoromethyl)phenyl]methyl]indole-2-carboxamide
CFAMM00382650 CHEMBL1760651 Bioactive 5-cyano-N-(3-hydroxy-2,2-dimethylpropyl)-1-[(2-methoxy-5-methylphenyl)methyl]indole-2-carboxamide
CFAMM00382643 CHEMBL1760644 Bioactive 5-cyano-N-[[1-(1-hydroxyethyl)cyclopentyl]methyl]-1-[[3-(trifluoromethoxy)phenyl]methyl]indole-2-carboxamide
CFAMM00382636 CHEMBL1760661 Bioactive 5-cyano-N-(2-hydroxy-2-methylpropyl)-1-[[2-methoxy-5-(trifluoromethoxy)phenyl]methyl]indole-2-carboxamide
CFAMM00382642 CHEMBL1760647 Bioactive 5-cyano-1-[[2-ethoxy-5-(trifluoromethoxy)phenyl]methyl]-N-(3-hydroxy-2,2-dimethylpropyl)indole-2-carboxamide
CFAMM00382635 CHEMBL1760669 Bioactive 5-cyano-N-[2-(1-hydroxycyclobutyl)ethyl]-1-[[3-(trifluoromethoxy)phenyl]methyl]indole-2-carboxamide
CFAMM00382641 CHEMBL1760646 Bioactive 5-cyano-N-(3-hydroxy-2,2-dimethylpropyl)-1-[[2-methoxy-5-(trifluoromethoxy)phenyl]methyl]indole-2-carboxamide
CFAMM00382654 CHEMBL1760658 Bioactive 1-[(5-tert-butyl-2-methoxyphenyl)methyl]-5-cyano-N-[[1-(hydroxymethyl)cyclopropyl]methyl]indole-2-carboxamide
CFAMM00382634 CHEMBL1760668 Bioactive 5-cyano-N-[2-(1-hydroxycyclobutyl)ethyl]-1-[[2-methoxy-5-(trifluoromethyl)phenyl]methyl]indole-2-carboxamide
CFAMM00382640 CHEMBL1760666 Bioactive 5-cyano-N-(4,4,4-trifluoro-3-hydroxybutyl)-1-[[3-(trifluoromethoxy)phenyl]methyl]indole-2-carboxamide
CFAMM00382653 CHEMBL1760656 Bioactive 5-cyano-N-[[1-(hydroxymethyl)cyclopropyl]methyl]-1-[[2-methoxy-5-(trifluoromethoxy)phenyl]methyl]indole-2-carboxamide
CFAMM00382639 CHEMBL1760665 Bioactive 5-cyano-N-(3-hydroxybutyl)-1-[[3-(trifluoromethoxy)phenyl]methyl]indole-2-carboxamide
CFAMM00382652 CHEMBL1760657 Bioactive 5-cyano-N-[[1-(hydroxymethyl)cyclopropyl]methyl]-1-[[2-methoxy-5-(trifluoromethyl)phenyl]methyl]indole-2-carboxamide
CFAMM00382645 CHEMBL1760667 Bioactive 5-cyano-N-[4,4,4-trifluoro-3-hydroxy-3-(trifluoromethyl)butyl]-1-[[3-(trifluoromethoxy)phenyl]methyl]indole-2-carboxamide
CFAMM00382638 CHEMBL1760663 Bioactive 5-cyano-N-(3-hydroxy-3-methylbutyl)-1-[[3-(trifluoromethoxy)phenyl]methyl]indole-2-carboxamide
CFAMM00382651 CHEMBL1760655 Bioactive 5-cyano-N-(3-hydroxy-2,2-dimethylpropyl)-1-[(3-propoxyphenyl)methyl]indole-2-carboxamide
CFAMM00382644 CHEMBL1760645 Bioactive 5-cyano-N-(3-hydroxy-2,2-dimethylpropyl)-1-[[3-(trifluoromethoxy)phenyl]methyl]indole-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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