CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7724
Family Name Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethylpropyl)-1-[[2-methyl-5-(trifluoromethyl)phenyl]methyl]indole-2-carboxamide family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00382665 Functional Category Bioactive
Superfamily Cannabinoid receptor 1 and Translocator protein Binder Superfamily
Class Class 929

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
CP-18770 family 6 27
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
NF-kappa-B and Protein kinase C zeta type Inhibitor Go6976 Family 9 71
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Vascular endothelial growth factor receptor 2 Ligand Isoindoli... 11 36
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Transient receptor potential cation channel subfamily V member... 6 23
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Endothelin B receptor Ligand IRL-2500 Family 34 87
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Metabotropic glutamate receptor 5 Ligand 1-(3-(2-methylquinoli... 2 12
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Pol polyprotein inhibitor N-[(2S)-1-[[(2S,3R,4S,5S)-3,4-dihydr... 2 0
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
ALK tyrosine kinase receptor and Insulin receptor ligand 9-eth... 9 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 2 5
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family 7 2
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 14 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Motilin receptor ligand SureCN2768052 family 3 0
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
High affinity nerve growth factor receptor ligand CHEMBL254555... 2 2
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 1 0
Coagulation factor X and Prothrombin inhibitor N,1-bis[(3-carb... 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Histamine H3 receptor ligand SureCN3542210 family 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Nuclear receptor ROR-gamma and Prelamin-A/C ligand CHEMBL14461... 1 18
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00382662 CHEMBL1760660 Bioactive 5-cyano-1-[(5-fluoro-2-methylphenyl)methyl]-N-[[1-(hydroxymethyl)cyclobutyl]methyl]indole-2-carboxamide
CFAMM00382666 CHEMBL1760654 Bioactive 5-cyano-1-[(2,5-dimethylphenyl)methyl]-N-(3-hydroxy-2,2-dimethylpropyl)indole-2-carboxamide
CFAMM00382665 CHEMBL1760652 Bioactive 5-cyano-N-(3-hydroxy-2,2-dimethylpropyl)-1-[[2-methyl-5-(trifluoromethyl)phenyl]methyl]indole-2-carboxamide
CFAMM00382663 CHEMBL1760664 Bioactive 5-cyano-N-(3-hydroxy-3-methylbutyl)-1-[[2-methyl-5-(trifluoromethyl)phenyl]methyl]indole-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45603 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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