CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7763
Family Name Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 4-methyl-3-(4-pentylphenyl)-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazole family
No. of Seeds 11 No. of Other Members 12
Family Centroid CFAMM00382851 Functional Category Bioactive
Superfamily Corticosteroid 11-beta-dehydrogenase isozyme 1 and Dipeptidyl peptidase 4 Binder Superfamily
Class Class 3082

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 9
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Type-2 angiotensin II receptor Ligand SC-50560 Family 3 84
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 16
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074WB2... 1 3
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 17
Hormone-sensitive lipase and Cholinesterase inhibitor N,N-dime... 3 3
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13680... 1 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 17 10
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 6 18
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 5-[4-... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 2 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 4 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 2 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 2 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
Metabotropic glutamate receptor 2 ligand 3-(cyclopropylmethyl)... 1 1
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 2,... 4 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-(2,... 3 0
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[2-... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-(2-... 4 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-met... 2 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3,5-b... 4 6
Type-1B angiotensin II receptor and Type-1 angiotensin II rece... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 0
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Type-1 angiotensin II receptor ligand SureCN9402249 family 4 7
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 2 0
Serine/threonine-protein kinase pim-1 and Glycogen synthase ki... 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[2-... 9 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 17 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00382864 CHEMBL258388 Bioactive 4-methyl-3,5-bis[2-(trifluoromethyl)phenyl]-1,2,4-triazole
CFAMM00382850 CHEMBL254789 Bioactive 3-(4-butyl-2-methylphenyl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazole
CFAMM00382863 CHEMBL1761138 Bioactive AGN-PC-0A9TWK
CFAMM00382855 CHEMBL383352 Bioactive SureCN13784342
CFAMM00382862 CHEMBL1761139 Bioactive AGN-PC-0A9RCL
CFAMM00382854 CHEMBL257752 Bioactive 3-(1-fluoronaphthalen-2-yl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazole
CFAMM00382861 CHEMBL403758 Bioactive 4-methyl-3-(7-methylnaphthalen-2-yl)-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazole
CFAMM00382867 CHEMBL256298 Bioactive 3-(2-bromophenyl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazole
CFAMM00382851 CHEMBL401988 Bioactive 4-methyl-3-(4-pentylphenyl)-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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