CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7768
Family Name Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-1-ethylimidazo[4,5-b]pyridin-2-one family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00382906 Functional Category Bioactive
Superfamily MK-3328 Superfamily
Class Class 681

Cousin Family NamesSeedsMembers
Kinetin family 2 39
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
MK-3328 family 2 32
MK-6096 family 3 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand CGS-15... 24 47
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Fatty-acid amide hydrolase 1 Inhibitor 1-(oxazolo[4,5-b]pyridi... 19 34
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Mitogen-activated protein kinase 14 Inhibitor CP-808844 Family 39 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Coagulation factor X and Prothrombin Inhibitor BMS-344577 Family 13 12
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Sodium-dependent serotonin transporter Inhibitor 4-furan-2-yl-... 2 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Divapl... 3 47
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Potassium voltage-gated channel subfamily H member 2 and Neuro... 3 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 20 28
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 3
Histamine H4 receptor and Histamine H3 receptor ligand SureCN6... 17 51
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 1
Adenosine receptor A2a ligand SureCN6867940 family 13 13
Receptor-type tyrosine-protein kinase FLT3 and Hepatocyte grow... 7 56
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 6 9
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Ferritin light chain and Ras-related protein Rab-9A inhibitor ... 1 11
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Survival motor neuron protein and Neuropeptide S receptor liga... 1 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 5 8
Adenosine receptor A2b and Adenosine receptor A2a ligand AGN-P... 2 0
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
Adenosine kinase inhibitor 7-[(4aS,7aS)-6-benzyl-3,4,4a,5,7,7a... 2 1
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
5-hydroxytryptamine receptor 1F ligand AGN-PC-075AYH family 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 5
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 2 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor CHEM... 1 0
Histamine H4 receptor ligand 8-fluoro-4-[(3R)-3-(methylamino)p... 6 1
Histamine H4 receptor ligand 8-chloro-4-[(3R)-3-(methylamino)p... 1 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1938684 ... 5 6
Prothrombin inhibitor SureCN6925359 family 6 18
Adenosine receptor A2a ligand 9-[(6-chloro-1,3-benzodioxol-5-y... 1 0
Histamine H3 receptor ligand 2-(4-piperidin-1-ylpiperidin-1-yl... 1 3
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 1 0
Hepatocyte growth factor receptor ligand 2-[2-amino-5-(1-piper... 4 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Tyrosine-protein kinase SYK inhibitor 4-[[3-[8-[(5,6-dimethoxy... 2 0
Scavenger receptor class B member 1 ligand 2-[9-[3-(4,6-dimeth... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 6
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 2
Adenosine receptor A2a and Adenosine receptor A1 ligand 5-[(7S... 6 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 4
Mitogen-activated protein kinase kinase kinase 7 and TGF-beta-... 3 14
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 25 5
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 29 1
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 1 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-075YVI ... 1 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 3 0
Platelet-activating factor receptor ligand AGN-PC-00GDIY family 1 1
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-03J2ZU f... 1 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 2
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 2
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 0
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 4 4
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 1 0
Fatty-acid amide hydrolase 1 inhibitor (Z)-1-(4-pyrimidin-4-yl... 1 0
Histamine H3 receptor ligand 9-[2-(4-piperidin-1-ylpiperidin-1... 1 3
Metabotropic glutamate receptor 5 ligand AGN-PC-09QKEE family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00382906 CHEMBL1761284 Bioactive 3-[(3R)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-1-ethylimidazo[4,5-b]pyridin-2-one
CFAMM00382905 CHEMBL1761285 Bioactive 3-[(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-1-ethylimidazo[4,5-b]pyridin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48716 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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