CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7781
Family Name 5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic receptor ligand (6R)-8-fluoro-6-(4-methylpiperazin-1-yl)-5,6-dihydropyrrolo[2,1-b][1,3]benzothiazepine family
No. of Seeds 8 No. of Other Members 6
Family Centroid CFAMM00323188 Functional Category Bioactive
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Binder Superfamily 12
Class Class 1800

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
Cytochrome P450 3A4 Inhibitor 3-(3-methylthiophen-2-yl)pyridin... 5 27
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264... 6 32
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Histamine H3 receptor Ligand ST-1025 Family 2 22
Translocator protein Inhibitor 5-phenyl-6-thia-10b-aza-benzo[e... 1 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 20
Histamine H1 receptor and Cytochrome P450 2D6 ligand 2-[3-[(1R... 1 10
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 8
D(2) dopamine receptor and D(3) dopamine receptor ligand 8-chl... 6 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 3 7
Histamine H1 receptor and Cytochrome P450 2D6 ligand N-methyl-... 1 0
Amyloid beta A4 protein and Luciferin 4-monooxygenase inhibito... 11 46
5-hydroxytryptamine receptor 1A and Alpha-2C adrenergic recept... 2 2
Amyloid beta A4 protein inhibitor SureCN2465837 family 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00383000 CHEMBL366679 Bioactive SureCN6208249

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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