CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7806
Family Name Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protein kinase Src inhibitor AGN-PC-04TF6V family
No. of Seeds 11 No. of Other Members 2
Family Centroid CFAMM00163276 Functional Category Bioactive
Superfamily Ephrin type-B receptor 4 and Tyrosine-protein kinase Lck Binder Superfamily
Class Class 1055

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 15 457
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
AP26113 family 16 90
GDC-0349 family 44 77
JAK Inhibitor Momelotinib Family 33 83
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Adenosine kinase inhibitor abt-702 family 14 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Adenosine kinase inhibitor 5-[3-(3-bromophenyl)propyl]-6-[2-(6... 3 0
Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... 11 0
Sorbitol dehydrogenase inhibitor SureCN6335187 family 2 6
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand 2xvd family 2 0
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 1 4
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 2 0
Transient receptor potential cation channel subfamily V member... 2 1
Tyrosine-protein kinase BTK and Dual specificity protein kinas... 1 0
Transient receptor potential cation channel subfamily V member... 4 0
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0074... 2 3
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Epidermal growth factor receptor ligand N-[3-[2-(4-morpholin-4... 2 2
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Adenosine kinase inhibitor SureCN8248615 family 2 3
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Cannabinoid receptor 2 ligand SureCN1626177 family 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00383326 CHEMBL1762538 Bioactive SureCN4441410
CFAMM00383332 CHEMBL1762547 Bioactive AGN-PC-0A9RUP
CFAMM00383325 CHEMBL1762537 Bioactive SureCN5126643
CFAMM00383331 CHEMBL1762540 Bioactive AGN-PC-0A9T4S
CFAMM00383324 CHEMBL1762550 Bioactive SureCN3671176
CFAMM00383330 CHEMBL1762541 Bioactive SureCN4554341
CFAMM00383323 CHEMBL1762531 Bioactive SureCN4435500
CFAMM00383329 CHEMBL1762548 Bioactive AGN-PC-0A9SIM
CFAMM00383327 CHEMBL1762539 Bioactive SureCN4429028

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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