CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7819
Family Name Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, mitochondrial inhibitor AGN-PC-076LUA family
No. of Seeds 9 No. of Other Members 7
Family Centroid CFAMM00383417 Functional Category Bioactive
Superfamily Acetylcholinesterase and Cytochrome P450 11B1, mitochondrial Binder Superfamily
Class Class 1542

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Indeglitazar family 3 39
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
C-C chemokine receptor type 5 ligand (2,4-dimethyl-1-oxidopyri... 5 4
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Gonadotropin-releasing hormone receptor ligand 1-[(2,6-difluor... 6 31
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 6 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 5
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
Histamine H3 receptor ligand SureCN2784306 family 5 3
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 3 3
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 2 2
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 1
Histamine H3 receptor ligand 3-[4-[3-[(2R)-2-methylpyrrolidin-... 1 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 0
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 1
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(... 1 0
Transient receptor potential cation channel subfamily V member... 6 1
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 2 6
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 5
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 4 1
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 12
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00383420 CHEMBL457646 Bioactive AGN-PC-04XDWT
CFAMM00383419 CHEMBL1765208 Bioactive AGN-PC-076LUC
CFAMM00383418 CHEMBL1765209 Bioactive SureCN1762309
CFAMM00383411 CHEMBL457856 Bioactive AGN-PC-04XE1U
CFAMM00383417 CHEMBL1765207 Bioactive AGN-PC-076LUA
CFAMM00383410 CHEMBL1765210 Bioactive SureCN1762183
CFAMM00383416 CHEMBL1765227 Bioactive AGN-PC-076MDI

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26186 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543