CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7821
Family Name Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,4aR,8aS)-4-hydroxy-4-phenyl-2,3,4a,5,6,7,8,8a-octahydroquinolin-1-yl]-quinolin-3-ylmethanone family
No. of Seeds 5 No. of Other Members 2
Family Centroid CFAMM00383428 Functional Category Bioactive
Superfamily Cannabinoid receptor 2 and Cannabinoid receptor 1 Binder Superfamily 9
Class Class 3108

Cousin Family NamesSeedsMembers
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Retinoic acid receptor alpha Ligand LG100268 Family 2 33
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
PF-4136309 family 16 27
Dihydroorotate dehydrogenase Inhibitor Cinchoninic Acid Family 1 21
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Lethal factor Inhibitor 3-(2,5-dimethyl-1h-pyrrol-1-yl)benzoic... 2 44
Fatty acid-binding protein, adipocyte Inhibitor 1-benzyl-2,3-d... 1 8
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 5 69
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family 3 41
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Prostaglandin E2 receptor EP4 subtype and Prostaglandin D2 rec... 8 17
Melanocortin receptor 4 and Potassium voltage-gated channel su... 2 12
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Sodium-dependent serotonin transporter and D(2) dopamine recep... 13 2
NS5B protein inhibitor AC1NQMYG family 6 12
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4R,... 3 7
Retinoic acid receptor alpha and Retinoic acid receptor beta l... 1 2
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 4 7
Metabotropic glutamate receptor 1 ligand [11C]JNJ-16567083 family 9 2
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Glycogen synthase kinase-3 beta inhibitor AGN-PC-0802SH family 1 2
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 2 2
Histone deacetylase inhibitor (3S,6S,9S,12R)-3-[(2S)-butan-2-y... 1 0
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
NS5B protein inhibitor AC1NQMYP family 5 0
C-C chemokine receptor type 2 ligand N-[2-[[(3R)-1-(4-hydroxy-... 4 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C9 liga... 2 6
Cannabinoid receptor 1 ligand (4-hydroxynaphthalen-1-yl)-[1-(2... 2 0
Platelet-activating factor receptor ligand SureCN9852997 family 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1,1,1... 12 3
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 2
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 1 1
Glutamate carboxypeptidase 2 inhibitor 1-[(3-carboxyphenyl)met... 4 11
Methionine aminopeptidase 1 inhibitor ethyl 4-[4-(2-pyridin-2-... 2 3
ATP-sensitive inward rectifier potassium channel 11 ligand N-[... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00383431 CHEMBL1765265 Bioactive [(4S,4aR,8aS)-4-hydroxy-4-phenyl-2,3,4a,5,6,7,8,8a-octahydroquinolin-1-yl]-(3-fluoropyridin-4-yl)methanone
CFAMM00383430 CHEMBL1765260 Bioactive [(4S,4aR,8aS)-4-hydroxy-4-phenyl-2,3,4a,5,6,7,8,8a-octahydroquinolin-1-yl]-(1,6-naphthyridin-2-yl)methanone
CFAMM00383428 CHEMBL1765258 Bioactive [(4S,4aR,8aS)-4-hydroxy-4-phenyl-2,3,4a,5,6,7,8,8a-octahydroquinolin-1-yl]-quinolin-3-ylmethanone
CFAMM00383427 CHEMBL1765276 Bioactive [(4S,4aR,8aS)-4-hydroxy-4-phenyl-2,3,4a,5,6,7,8,8a-octahydroquinolin-1-yl]-(6-methylpyridin-3-yl)methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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