CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7823
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform inhibitor AGN-PC-09M1B0 family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00383437 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and Serine/threonine-protein kinase mTOR Binder Superfamily
Class Class 853

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
ATP-sensitive inward rectifier potassium channel 10 Ligand Gli... 2 45
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Translocator protein Inhibitor Emapunil Family 7 89
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Reverse transcriptase Inhibitor Benzothiadiazines Family 4 21
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Protein farnesyltransferase subunit beta Inhibitor BMS-316810 ... 11 18
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor SureCN5856722 family 3 16
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 4
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M4U... 4 5
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Platelet-activating factor receptor ligand 6-(4-fluorophenyl)-... 1 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 1
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
C-C chemokine receptor type 2 ligand 4-chloro-N-[5-methyl-2-(7... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 5
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Dipeptidyl peptidase 4 inhibitor 2-(3-aminopiperidin-1-yl)-3-b... 4 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(4,5-dichlo... 1 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family 7 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 9 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00383438 CHEMBL1765463 Bioactive AGN-PC-09M1B2
CFAMM00383437 CHEMBL1765461 Bioactive AGN-PC-09M1B0

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27254 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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