CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7824
Family Name Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluorophenyl)sulfonyl-3-[5-fluoro-1-(imidazo[1,2-a]pyridin-2-ylmethyl)-3-methylindol-7-yl]prop-2-enamide family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00383441 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and Serine/threonine-protein kinase mTOR Binder Superfamily
Class Class 853

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Histamine H1 receptor Ligand Mizolastine Family 14 603
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Thromboxane A2 receptor Ligand Ramatroban Family 13 49
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Translocator protein Inhibitor Emapunil Family 7 89
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
GDC-0349 family 44 77
PF-4217903 family 14 65
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Protein farnesyltransferase subunit beta Inhibitor BMS-316810 ... 11 18
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 8
Type-2 angiotensin II receptor and Type-1A angiotensin II rece... 10 7
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor SureCN5856722 family 3 16
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Thromboxane-A synthase inhibitor AGN-PC-00N7V2 family 3 6
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 21
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 4
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M4U... 4 5
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M46L fa... 2 7
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M770 fa... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 12
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Platelet-activating factor receptor ligand 6-(4-fluorophenyl)-... 1 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 1
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 15
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 22
Thromboxane A2 receptor and Thromboxane-A synthase ligand AGN-... 2 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 12 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-b]pyridazine d... 2 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(4,5-dichlo... 1 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family 7 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00383441 CHEMBL566197 Bioactive (E)-N-(3,4-difluorophenyl)sulfonyl-3-[5-fluoro-1-(imidazo[1,2-a]pyridin-2-ylmethyl)-3-methylindol-7-yl]prop-2-enamide
CFAMM00383440 CHEMBL1765626 Bioactive AGN-PC-09M1GE
CFAMM00383439 CHEMBL566429 Bioactive (E)-N-(3,5-difluorophenyl)sulfonyl-3-[5-fluoro-1-(imidazo[1,2-a]pyridin-2-ylmethyl)-3-methylindol-7-yl]prop-2-enamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27264 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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