CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7825
Family Name Substance-P receptor and Neuromedin-K receptor ligand SureCN8821413 family
No. of Seeds 4 No. of Other Members 14
Family Centroid CFAMM00383447 Functional Category Bioactive
Superfamily ABC294640 Superfamily
Class Class 913

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
HIV protease Inhibitor Saquinavir Family 64 428
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
26S proteasome Inhibitor Bortezomib Family 7 65
Prothrombin Inhibitor Ximelegatran Family 8 157
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Substance-P receptor Ligand TAK-637 Family 18 63
ABC294640 family 5 75
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Inhibitor of nuclear factor kappa-B kinase subunit epsilon and... 1 4
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Amine oxidase [flavin-containing] B Inhibitor Lazebemide Family 2 13
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Gonadotropin-releasing hormone receptor Ligand [d-ncy(methyl)4... 32 0
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Peroxisome proliferator-activated receptor gamma Ligand 2-chlo... 5 19
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 3 7
Vasopressin V2 receptor and Vasopressin V1a receptor ligand [2... 2 5
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 4
Cholecystokinin receptor type A ligand A-65186 family 2 6
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Cannabinoid receptor 1 ligand AGN-PC-04YSUM family 7 6
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Vasopressin V1b receptor ligand 2-[3-(3-chlorophenyl)-1-oxo-7-... 2 12
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
B1 bradykinin receptor ligand ELN-441958 family 1 0
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Cellular tumor antigen p53 and Ferritin light chain inhibitor ... 1 2
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Metabotropic glutamate receptor 2 ligand AGN-PC-00A1HD family 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 2
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 2 4
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Renin inhibitor (3R,4S)-N-cyclopropyl-N-[[2-(3-methoxypropyl)q... 2 0
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Nicotinamide phosphoribosyltransferase inhibitor 4-[[(7-chloro... 1 1
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 4 10
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
Glycogen synthase kinase-3 beta inhibitor 7-(6-chloropyridin-2... 2 3
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12
C-C chemokine receptor type 5 ligand N-[3-[4-[4-bromo-N-[(3-cy... 2 4
Delta-type opioid receptor and Potassium voltage-gated channel... 2 0
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 10 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 2 9
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 1 0
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 1 1
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Substance-P receptor ligand SureCN7796965 family 9 1
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 8 1
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 2 11
Neuromedin-K receptor and Potassium voltage-gated channel subf... 13 2
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Cannabinoid receptor 1 ligand SureCN4454684 family 2 0
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Motilin receptor ligand SureCN2768052 family 3 0
C-C chemokine receptor type 2 ligand SureCN5946889 family 2 6
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
Acetylcholinesterase inhibitor N-[6-[4-[(6-chloro-1,2,3,4-tetr... 9 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
C-C chemokine receptor type 2 ligand (E)-3-(3,4-dichlorophenyl... 3 2
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Substance-K receptor and Substance-P receptor ligand 3,5-dichl... 3 0
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Chymase inhibitor SureCN408571 family 1 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 1
KiSS-1 receptor ligand SureCN5132924 family 2 4
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
C-X-C chemokine receptor type 3 ligand N-[3-[7-chloro-3-[2-(4-... 2 5
Coagulation factor X and Prothrombin inhibitor N,1-bis[(3-carb... 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Cytochrome P450 2C9 inhibitor AGN-PC-04XDND family 1 3
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 3 0
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Mitogen-activated protein kinase 14 inhibitor SureCN14185127 f... 2 0
Translocator protein inhibitor 2-(7-Chloro-5-methyl-4-oxo-3-ph... 1 0
P2X purinoceptor 7 inhibitor 2-chloro-N-[(1-hydroxy-3,3-dimeth... 1 8
Poly [ADP-ribose] polymerase 1 inhibitor SureCN3553433 family 22 0
Cannabinoid receptor 1 ligand AGN-PC-07R6NY family 2 0
C-C chemokine receptor type 3 ligand AGN-PC-075CFA family 3 1
C-C chemokine receptor type 5 ligand methyl 4-[benzyl-[1-[4-[(... 1 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00383449 CHEMBL191464 Bioactive AGN-PC-075IHF
CFAMM00383447 CHEMBL43912 Bioactive SureCN8821413

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26853 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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