CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7828
Family Name Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00383467 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 2A and Mitogen-activated protein kinase 14 Binder Superfamily
Class Class 840

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Hepatocyte growth factor receptor Ligand MK-8033 Family 19 42
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
NF-kappa-B and Protein kinase C zeta type Inhibitor Go6976 Family 9 71
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Vascular endothelial growth factor receptor 2 Ligand Isoindoli... 11 36
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 19 12
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Vascular endothelial growth factor receptor 2 and Angiopoietin... 4 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 4
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Serine/threonine-protein kinase mTOR and DNA-dependent protein... 6 7
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Metabotropic glutamate receptor 1 ligand GTPL6334 family 6 4
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 5 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Calcitonin gene-related peptide type 1 receptor ligand 2-[(7-m... 3 0
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 5
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 3 2
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 9 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Serine/threonine-protein kinase Chk1 inhibitor 5-[(2S)-3-amino... 4 6
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 1 0
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 2
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Calcitonin gene-related peptide type 1 receptor ligand [(2R)-3... 2 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00383467 CHEMBL1765603 Bioactive AGN-PC-093LHN
CFAMM00383471 CHEMBL1765610 Bioactive AGN-PC-093LKW
CFAMM00383470 CHEMBL1795883 Bioactive N-(1-methylpiperidin-4-yl)-4-[4-[2-oxo-9-(1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-1-yl]-2-(trifluoromethyl)phenyl]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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