CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7836
Family Name Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-phenylphenyl)propanoyl]-1,3-oxazol-5-yl]pyridine-3-carboxylate family
No. of Seeds 8 No. of Other Members 5
Family Centroid CFAMM00383510 Functional Category Bioactive with Natural Product
Superfamily Sphingosine 1-phosphate receptor 1 and Beta-lactamase Binder Superfamily
Class Class 994

Cousin Family NamesSeedsMembers
Cyclooxygenase Inhibitor Oxaprozin Family 33 450
Pristinamycin family 2 2
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
Substance-P receptor Ligand R 673 Family 2 127
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-(b... 17 47
Fatty-acid amide hydrolase 1 Inhibitor (z)-1-(benzo[d]oxazol-2... 2 27
Fatty-acid amide hydrolase 1 Inhibitor 1-(oxazolo[4,5-b]pyridi... 19 34
Fatty-acid amide hydrolase 1 Inhibitor 1-(5-(pyridin-2-yl)oxaz... 10 142
Cytochrome P450 3A4 Inhibitor 3-(5-((methylthio)methyl)furan-2... 4 14
Prostacyclin receptor and Prostaglandin E2 receptor EP3 subtyp... 4 17
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-[5-(4-hydroxyphe... 4 36
Peroxisome proliferator-activated receptor alpha Ligand BMS-68... 10 16
Fatty-acid amide hydrolase 1 Inhibitor 7-phenyl-1-(5-phenyloxa... 3 3
Fatty-acid amide hydrolase 1 Inhibitor 1-(5-(furan-2-yl)oxazol... 2 1
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... 3 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 21
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Phospholipase A2 inhibitor SureCN7046992 family 2 3
Phospholipase A2 inhibitor 2-[2-ethyl-1-oxamoyl-3-[(5-thiophen... 1 0
Histone deacetylase 1 and Histone deacetylase 2 inhibitor AGN-... 4 15
Histone deacetylase 1 and Histone deacetylase 2 inhibitor 7-[5... 1 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Retinoic acid receptor beta and Retinoic acid receptor alpha l... 2 2
Fatty-acid amide hydrolase 1 inhibitor SureCN1471727 family 2 19
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Cytochrome P450 2C19 and Inositol monophosphatase 1 inhibitor ... 1 0
Inosine-5'-monophosphate dehydrogenase inhibitor SureCN1318237... 2 12
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
Histamine H3 receptor ligand SureCN2784306 family 5 3
Fatty-acid amide hydrolase 1 inhibitor [(2S)-6-phenoxy-1,2,3,4... 3 6
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Fatty-acid amide hydrolase 1 and Liver carboxylesterase 1 inhi... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,4S)-4-f... 4 7
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 1
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[6-propan-2-ylo... 1 1
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[4-phenyl-3-(tr... 2 3
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 14 24
Sphingosine 1-phosphate receptor 1 ligand AGN-PC-00DWQL family 2 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 3
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
Beta-secretase 1 and Cytochrome P450 3A4 inhibitor N-[(2S,3R)-... 3 7
Fatty-acid amide hydrolase 1 inhibitor methyl 5-[2-(7-phenylhe... 2 4
Peroxisome proliferator-activated receptor alpha and Peroxisom... 5 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 10 5
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Fatty-acid amide hydrolase 1 inhibitor alpha-ketooxazole, 4jj ... 1 1
Fatty-acid amide hydrolase 1 inhibitor alpha-ketooxazole, 5a f... 2 1
Inosine-5'-monophosphate dehydrogenase inhibitor 2-(2,3-dichlo... 2 0
Inosine-5'-monophosphate dehydrogenase inhibitor (2S)-2-(2,3-d... 4 1
Inosine-5'-monophosphate dehydrogenase inhibitor (2S)-2-naphth... 1 0
Cathepsin S inhibitor (2S,4R)-4-(benzenesulfonyl)-N-[1-(1,3-be... 4 0
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 5
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 1
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 3
Fatty-acid amide hydrolase 1 inhibitor N-methyl-2-[3-[4-(pheno... 1 0
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-04UH7Y family 4 1
Leukotriene A-4 hydrolase inhibitor SureCN3030546 family 9 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 3
Metabotropic glutamate receptor 5 ligand SureCN504754 family 5 4
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 2 3
Potassium voltage-gated channel subfamily H member 2 and ATP-s... 1 0
Metabotropic glutamate receptor 5 ligand 3-fluoro-5-(5-pyridin... 1 0
P2Y purinoceptor 1 inhibitor N-[2-(2-tert-butylphenoxy)pyridin... 1 0
Fatty-acid amide hydrolase 1 inhibitor 7-phenyl-1-[5-[6-(2H-te... 2 0
Reverse transcriptase/RNaseH inhibitor 3-[2-(1-benzofuran-2-yl... 1 1
Sodium channel protein type 10 subunit alpha ligand AGN-PC-09M... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00383509 CHEMBL260536 Bioactive methyl 6-[2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazol-5-yl]pyridine-3-carboxylate
CFAMM00383508 CHEMBL260534 Bioactive 6-[2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazol-5-yl]pyridine-3-carboxylic acid
CFAMM00383507 CHEMBL1765863 Bioactive AGN-PC-09MAQW
CFAMM00383497 CHEMBL1765871 Bioactive methyl 6-[2-[(2S)-5-phenylmethoxy-2,3-dihydro-1H-indene-2-carbonyl]-1,3-oxazol-5-yl]pyridine-2-carboxylate
CFAMM00383506 CHEMBL1765832 Bioactive methyl 6-[2-[(2S)-6-phenoxy-1,2,3,4-tetrahydronaphthalene-2-carbonyl]-1,3-oxazol-5-yl]pyridine-2-carboxylate
CFAMM00383496 CHEMBL270916 Bioactive methyl 6-[2-[3-[4-[4-(thiomorpholin-4-ylmethyl)phenyl]phenyl]propanoyl]-1,3-oxazol-5-yl]pyridine-2-carboxylate
CFAMM00383510 CHEMBL260746 Bioactive methyl 6-[2-[3-(4-phenylphenyl)propanoyl]-1,3-oxazol-5-yl]pyridine-3-carboxylate
CFAMM00383501 CHEMBL271745 Bioactive methyl 5-[2-[3-(4-phenylphenyl)propanoyl]-1,3-oxazol-5-yl]pyridine-2-carboxylate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27425 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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