CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7893
Family Name Histamine H4 receptor ligand 4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-6-N-propan-2-ylpyridine-2,6-diamine family
No. of Seeds 7 No. of Other Members 6
Family Centroid CFAMM00383922 Functional Category Bioactive
Superfamily SUR2-type K(ATP) channel Ligand Pinacidil Superfamily
Class Class 672

Cousin Family NamesSeedsMembers
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
SUR2-type K(ATP) channel Ligand Pinacidil Family 1 8
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
Transient receptor potential cation channel subfamily V member... 15 457
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Adenosine receptor A1 and Adenosine receptor A2a Ligand 3-benz... 1 6
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Cathepsin K Inhibitor 2-cyclohexylamino-pyridine-2-carbonitril... 1 2
Transient receptor potential cation channel subfamily V member... 2 26
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Urotensin-2 receptor Ligand Palosuran Family 4 4
Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... 2 22
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 4 5
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Bloom syndrome protein inhibitor SR 57227A family 2 12
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Acetylcholinesterase and Cholinesterase inhibitor 2-amino-6-[3... 1 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 3
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 10 1
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 2 0
Nitric oxide synthase, brain and Nitric oxide synthase, endoth... 1 0
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Microtubule-associated protein tau and Thyrotropin receptor li... 1 2
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00383928 CHEMBL1770975 Bioactive 6-N-(2,2-dimethylpropyl)-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridine-2,6-diamine
CFAMM00383921 CHEMBL1770968 Bioactive AGN-PC-0A9UCF
CFAMM00383931 CHEMBL1770973 Bioactive 6-N-cyclopentyl-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyridine-2,6-diamine
CFAMM00383924 CHEMBL1770964 Bioactive AGN-PC-09O561
CFAMM00383923 CHEMBL1770966 Bioactive AGN-PC-09O560
CFAMM00383929 CHEMBL1770971 Bioactive 4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-6-N-(2-methylpropyl)pyridine-2,6-diamine
CFAMM00383922 CHEMBL1770969 Bioactive 4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-6-N-propan-2-ylpyridine-2,6-diamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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