CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7916
Family Name Serine/threonine-protein kinase mTOR inhibitor SureCN2707225 family
No. of Seeds 29 No. of Other Members 4
Family Centroid CFAMM00384049 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase mTOR and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Binder Superfamily 4
Class Class 3274

Cousin Family NamesSeedsMembers
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
GDC-0349 family 44 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
JAK Inhibitor Momelotinib Family 33 83
Toll-like receptor 7 Ligand GS-9620 Family 2 4
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 25 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... 4 5
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-088SNX f... 1 0
Serine/threonine-protein kinase mTOR inhibitor SureCN3776855 f... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Transient receptor potential cation channel subfamily V member... 4 0
Growth hormone secretagogue receptor type 1 ligand SureCN63605... 5 7
Growth hormone secretagogue receptor type 1 ligand SureCN62436... 8 6
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0074... 2 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 2-[4... 5 5
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
Substance-P receptor and Sodium-dependent serotonin transporte... 11 4
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 1 2
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00384031 CHEMBL1774363 Bioactive SureCN2707063
CFAMM00384044 CHEMBL1774373 Bioactive SureCN2709409
CFAMM00384024 CHEMBL1774369 Bioactive SureCN2708631
CFAMM00384050 CHEMBL1774354 Bioactive SureCN2711190
CFAMM00384030 CHEMBL1774362 Bioactive SureCN2709341
CFAMM00384043 CHEMBL1774374 Bioactive SureCN2709242
CFAMM00384023 CHEMBL1774368 Bioactive SureCN3777703
CFAMM00384036 CHEMBL1773085 Bioactive SureCN2709611
CFAMM00384049 CHEMBL1774355 Bioactive SureCN2707225
CFAMM00384029 CHEMBL1774361 Bioactive SureCN2708263
CFAMM00384042 CHEMBL1774375 Bioactive SureCN2707611
CFAMM00384035 CHEMBL1774367 Bioactive SureCN2711184
CFAMM00384048 CHEMBL1774352 Bioactive AGN-PC-09O6RF
CFAMM00384028 CHEMBL1774360 Bioactive SureCN2708117
CFAMM00384041 CHEMBL1774376 Bioactive SureCN3778269
CFAMM00384034 CHEMBL1774366 Bioactive SureCN2709657
CFAMM00384047 CHEMBL1774353 Bioactive SureCN2709832
CFAMM00384027 CHEMBL1774381 Bioactive SureCN2709437
CFAMM00384040 CHEMBL1774377 Bioactive SureCN2708019
CFAMM00384053 CHEMBL1774359 Bioactive SureCN2709590
CFAMM00384033 CHEMBL1774365 Bioactive SureCN3778333
CFAMM00384046 CHEMBL1774370 Bioactive SureCN2710080
CFAMM00384026 CHEMBL1774380 Bioactive SureCN2708725
CFAMM00384052 CHEMBL1774356 Bioactive SureCN2708251
CFAMM00384032 CHEMBL1774364 Bioactive SureCN3787242
CFAMM00384045 CHEMBL1774371 Bioactive 1-[4-[(7S)-7-[2-(dimethylamino)ethyl]-7-methyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylurea
CFAMM00384025 CHEMBL1774382 Bioactive SureCN2709853
CFAMM00384038 CHEMBL1774379 Bioactive SureCN2710208
CFAMM00384051 CHEMBL1774357 Bioactive SureCN2708284

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27270 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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