CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7919
Family Name Glucose-dependent insulinotropic receptor ligand 4-({Ethyl-[1-(4-methanesulfonyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester family
No. of Seeds 6 No. of Other Members 12
Family Centroid CFAMM00384067 Functional Category Bioactive
Superfamily Cyclooxygenase 2 and Glucose-dependent insulinotropic receptor Binder Superfamily
Class Class 3175

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Hepatocyte growth factor receptor Ligand SGX523 Family 1 15
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 13 100
5-hydroxytryptamine receptor 6 ligand AGN-PC-0BIUF2 family 25 11
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(4-a... 8 11
5-hydroxytryptamine receptor 6 ligand 3-(3-chloro-4-fluorophen... 1 2
5-hydroxytryptamine receptor 6 ligand 3-(benzenesulfonyl)-N,5-... 4 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07CBUP family 2 3
Glucose-dependent insulinotropic receptor ligand 4-[1-(4-Metha... 9 22
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Casein kinase II subunit alpha inhibitor 7-(cyclopropylamino)-... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Glucose-dependent insulinotropic receptor ligand S-propan-2-yl... 1 4
Glucose-dependent insulinotropic receptor ligand AGN-PC-04YR3D... 11 9
Nicotinamide phosphoribosyltransferase inhibitor 1-[4-(1-methy... 1 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-0CSEAG family 2 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07R77D fa... 2 7
Cyclooxygenase 2 and Prostaglandin G/H synthase 1 inhibitor Su... 2 1


External ID

Functional Category

Molecule Name

CFAMM00384070 CHEMBL1773287 Bioactive AGN-PC-0A9QLE
CFAMM00384068 CHEMBL1773281 Bioactive SureCN386157
CFAMM00384069 CHEMBL1773286 Bioactive AGN-PC-0A9UHL
CFAMM00384067 CHEMBL1773280 Bioactive 4-({Ethyl-[1-(4-methanesulfonyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester
CFAMM00384066 CHEMBL1773283 Bioactive 4-[1-(2-Fluoro-4-methanesulfonyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylsulfanyl]-piperidine-1-carboxylic acid tert-butyl ester

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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