CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7931
Family Name Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 inhibitor SureCN2490059 family
No. of Seeds 2 No. of Other Members 4
Family Centroid CFAMM00384012 Functional Category Bioactive
Superfamily Aurora kinase A and Tyrosine-protein kinase Yes Binder Superfamily
Class Class 4596

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Metabotropic glutamate receptor 5 Ligand 3-(1-pyridin-2-yl-1h-... 3 6
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 5
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
3-phosphoinositide-dependent protein kinase 1 and Rho-associat... 12 11
Tyrosine-protein kinase JAK2 inhibitor SureCN217071 family 1 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 9 3
Aurora kinase A and Tyrosine-protein kinase Yes inhibitor AGN-... 4 0
Aurora kinase A inhibitor AGN-PC-0A9UUA family 4 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 3 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 3 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 1
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Motilin receptor ligand SureCN2004322 family 2 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 0
Mast/stem cell growth factor receptor Kit and Proto-oncogene t... 3 5
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
High affinity nerve growth factor receptor ligand SureCN333709... 4 5
High affinity nerve growth factor receptor ligand SureCN490352... 3 0
Aurora kinase A and Glycogen synthase kinase-3 beta inhibitor ... 2 0
Aurora kinase A inhibitor SureCN2205392 family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00384215 CHEMBL1774055 Bioactive AZ 960

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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