CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7941
Family Name Sigma non-opioid intracellular receptor 1 ligand methyl (1R,2S)-2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-phenylcyclopropane-1-carboxylate family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00384242 Functional Category Bioactive
Superfamily Histamine H1 receptor and Mu-type opioid receptor Binder Superfamily
Class Class 232

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Terfenadine Family 3 50
Alpha-2 adrenergic receptor ligand opiate Meperidine Family 13 76
D(2) dopamine receptor Ligand Haloperidol Family 5 53
Histamine H1 receptor Ligand Levocabastine Family 1 1
Muscarinic acetylcholine receptor Ligand Flutropium Bromide Fa... 6 45
Delta-type opioid receptor Ligand Loperamide Family 8 55
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Muscarinic acetylcholine receptor Ligand Mepenzolate Family 35 11
Muscarinic acetylcholine receptor M1 Ligand Oxyphenonium Family 12 5
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Sodium- and chloride-dependent GABA transporter 3 Inhibitor SN... 1 4
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Sodium-dependent noradrenaline transporter Inhibitor (r)-1-((s... 3 8
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor 2-[4-[[1-(2,... 2 7
Sigma non-opioid intracellular receptor 1 ligand SureCN5315520... 3 11
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-04TFA0... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Sodium- and chloride-dependent GABA transporter 1 inhibitor (3... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00384241 CHEMBL1774578 Bioactive methyl (1S,2R)-2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-phenylcyclopropane-1-carboxylate
CFAMM00384240 CHEMBL385795 Bioactive methyl 2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methoxyphenyl)cyclopropane-1-carboxylate
CFAMM00384239 CHEMBL221348 Bioactive methyl 2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-phenylcyclopropane-1-carboxylate
CFAMM00384242 CHEMBL1774577 Bioactive methyl (1R,2S)-2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-phenylcyclopropane-1-carboxylate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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