CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7989
Family Name MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 family
No. of Seeds 2 No. of Other Members 5
Family Centroid CFAMM00384622 Functional Category Bioactive with Natural Product
Superfamily MK-3328 Superfamily
Class Class 681

Cousin Family NamesSeedsMembers
Kinetin family 2 39
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
MK-3328 family 2 32
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Mitogen-activated protein kinase 14 Inhibitor CP-808844 Family 39 43
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Divapl... 3 47
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Potassium voltage-gated channel subfamily H member 2 and Neuro... 3 4
Receptor-type tyrosine-protein kinase FLT3 and Hepatocyte grow... 7 56
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 6 9
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Survival motor neuron protein and Neuropeptide S receptor liga... 1 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 5 8
Adenosine receptor A2b and Adenosine receptor A2a ligand AGN-P... 2 0
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
5-hydroxytryptamine receptor 1F ligand AGN-PC-075AYH family 2 1
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 6 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor CHEM... 1 0
Histamine H4 receptor ligand 8-fluoro-4-[(3R)-3-(methylamino)p... 6 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1938684 ... 5 6
Prothrombin inhibitor SureCN6925359 family 6 18
Adenosine receptor A2a ligand 9-[(6-chloro-1,3-benzodioxol-5-y... 1 0
Histamine H3 receptor ligand 2-(4-piperidin-1-ylpiperidin-1-yl... 1 3
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Adenosine receptor A2b ligand 2-[5-(2,6-dioxo-1,3-dipropyl-7H-... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
Tyrosine-protein kinase SYK inhibitor 4-[[3-[8-[(5,6-dimethoxy... 2 0
Scavenger receptor class B member 1 ligand 2-[9-[3-(4,6-dimeth... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Adenosine receptor A2a and Adenosine receptor A1 ligand 5-[(7S... 6 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 1
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 4
Tyrosine-protein kinase ITK/TSK and Aurora kinase B inhibitor ... 1 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 29 1
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-075YVI ... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 3 0
Platelet-activating factor receptor ligand AGN-PC-00GDIY family 1 1
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... 6 15
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-03J2ZU f... 1 2
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 2
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 0
Metabotropic glutamate receptor 5 ligand AGN-PC-09QKEE family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00384624 CHEMBL66600 Bioactive AGN-PC-074E8Z
CFAMM00384622 CHEMBL1779352 Bioactive AGN-PC-09ODY0

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48716 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543