CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7990
Family Name MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG family
No. of Seeds 6 No. of Other Members 5
Family Centroid CFAMM00384630 Functional Category Bioactive
Superfamily Renin and Insulin-like growth factor 1 receptor Binder Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Smoothened homolog Inhibitor LDE225 Family 3 76
XL-888 family 16 85
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 4 4
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 7
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Aurora kinase A inhibitor SureCN761545 family 2 2
Aurora kinase A inhibitor SureCN761045 family 2 0
Transient receptor potential cation channel subfamily V member... 1 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801305 ... 2 0
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 1
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Scavenger receptor class B member 1 ligand methyl 9-[3-(4,6-di... 2 10
Heat shock protein HSP 90-beta inhibitor N-[(9R)-4-(3H-imidazo... 1 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Adenosine receptor A2b ligand 2-[5-(2,6-dioxo-1,3-dipropyl-7H-... 1 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Histamine H3 receptor ligand AGN-PC-075YVW family 1 2
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... 6 15
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00384630 CHEMBL1779363 Bioactive AGN-PC-0A9RSG
CFAMM00384636 CHEMBL1779374 Bioactive (7S)-2-[2-(5-methoxypyridin-3-yl)pyrimidin-4-yl]spiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,3'-piperidine]-4-one
CFAMM00384640 CHEMBL1779485 Bioactive SureCN1960187
CFAMM00384635 CHEMBL1801308 Bioactive CHEMBL1801308
CFAMM00384634 CHEMBL1801304 Bioactive CHEMBL1801304
CFAMM00384633 CHEMBL1801306 Bioactive CHEMBL1801306

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27038 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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