CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8004
Family Name Dipeptidyl peptidase 4 inhibitor (3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(ethoxymethyl)piperazin-2-one family
No. of Seeds 6 No. of Other Members 6
Family Centroid CFAMM00384705 Functional Category Bioactive
Superfamily Dipeptidyl peptidase 4 and Cytochrome P450 2D6 Binder Superfamily
Class Class 586

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
20S proteasome Inhibitor Carfilzomib Family 5 17
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Cytosolic phospholipase A2 Inhibitor Methyl 2-(2-oxo-8-phenylo... 2 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Substance-K receptor ligand (4S)-4-amino-1-[4-(oxan-4-ylmethyl... 1 2
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 3 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 5 11
Cruzipain and Cathepsin F inhibitor SureCN12999163 family 1 0
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 1 8
Cathepsin S inhibitor SureCN7062841 family 7 7
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 3 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2S... 16 24
Dipeptidyl peptidase 4 inhibitor (3S)-4-[(3R)-3-amino-4-(2,4,5... 1 1
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 16 1
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
Kappa-type opioid receptor ligand 1-[4-acetyl-2-[[(3S)-3-hydro... 2 1
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Renin inhibitor AGN-PC-076HPD family 1 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 15 0
Renin and Cathepsin D inhibitor N-[(2S)-1-[[(2S)-1-[[(2S)-1-cy... 2 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 10 0
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 0
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor SureC... 1 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 9 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 6
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00384706 CHEMBL1779706 Bioactive SureCN2296606
CFAMM00384705 CHEMBL1779707 Bioactive (3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(ethoxymethyl)piperazin-2-one
CFAMM00384709 CHEMBL1779708 Bioactive SureCN2298051
CFAMM00384708 CHEMBL1779709 Bioactive SureCN2299382
CFAMM00384700 CHEMBL1779710 Bioactive Evogliptin
CFAMM00384699 CHEMBL1779713 Bioactive SureCN2297938

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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