CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8014
Family Name Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L family
No. of Seeds 14 No. of Other Members 7
Family Centroid CFAMM00384787 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase Chk1 and Serine/threonine-protein kinase B-raf Binder Superfamily
Class Class 1666

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
PF-4217903 family 14 65
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Kappa-type opioid receptor and Potassium voltage-gated channel... 10 10
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Cytochrome P450 3A4 Inhibitor 5-(2-phenethylpiperazin-1-yl)-1h... 12 35
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 6
Corticotropin-releasing factor receptor 1 ligand 3,7-dimethyl-... 3 4
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Tyrosine-protein kinase ITK/TSK inhibitor (3Z)-3-(6-methylindo... 2 40
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 6
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Casein kinase I isoform delta and Casein kinase I isoform epsi... 1 0
Serine/threonine-protein kinase Chk1 inhibitor 5-[7-(2-morphol... 2 2
Sigma non-opioid intracellular receptor 1 ligand 1-phenyl-4-(2... 1 0
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 10 2
Nociceptin receptor ligand SureCN3543370 family 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4
Transient receptor potential cation channel subfamily V member... 1 0
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
TGF-beta receptor type-1 ligand 6-bromo-4-(2-(6-methylpyridin-... 1 3
TGF-beta receptor type-1 ligand SureCN373106 family 4 1
Farnesyl pyrophosphate synthase inhibitor AGN-PC-080IBX family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00384795 CHEMBL1780174 Bioactive AGN-PC-0A9TJV
CFAMM00384782 CHEMBL1780169 Bioactive 6-[1-(azepan-4-yl)-3-pyridin-4-ylpyrazol-4-yl]-1,4-dihydroindeno[1,2-c]pyrazole
CFAMM00384794 CHEMBL1780177 Bioactive 6-[1-[(3R,4R)-3-fluoropiperidin-4-yl]-3-pyridin-4-ylpyrazol-4-yl]-1,4-dihydroindeno[1,2-c]pyrazole
CFAMM00384787 CHEMBL1780165 Bioactive AGN-PC-00AP1L
CFAMM00384793 CHEMBL1780176 Bioactive AGN-PC-0A9U70
CFAMM00384792 CHEMBL1780179 Bioactive 6-[1-[(3R,4S)-4-fluoropiperidin-3-yl]-3-pyridin-4-ylpyrazol-4-yl]-1,4-dihydroindeno[1,2-c]pyrazole
CFAMM00384785 CHEMBL1780167 Bioactive AGN-PC-0A9SAL
CFAMM00384798 CHEMBL1780170 Bioactive AGN-PC-0A9RND
CFAMM00384791 CHEMBL1780178 Bioactive 6-[1-[(3S,4R)-3-fluoropiperidin-4-yl]-3-pyridin-4-ylpyrazol-4-yl]-1,4-dihydroindeno[1,2-c]pyrazole
CFAMM00384784 CHEMBL523261 Bioactive pyrazole-based inhibitor, 35
CFAMM00384797 CHEMBL1780173 Bioactive (1R,3S)-3-[4-(1,4-dihydroindeno[1,2-c]pyrazol-6-yl)-3-pyridin-4-ylpyrazol-1-yl]cyclohexan-1-ol
CFAMM00384783 CHEMBL1780180 Bioactive 6-[1-[(3S,4S)-3-fluoropiperidin-4-yl]-3-pyridin-4-ylpyrazol-4-yl]-1,4-dihydroindeno[1,2-c]pyrazole
CFAMM00384796 CHEMBL1780175 Bioactive (3R,4R)-4-[4-(1,4-dihydroindeno[1,2-c]pyrazol-6-yl)-3-pyridin-4-ylpyrazol-1-yl]piperidin-3-ol
CFAMM00384789 CHEMBL1780166 Bioactive AGN-PC-0A9SAK

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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