CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8025
Family Name Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta inhibitor AGN-PC-046PXY family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00384900 Functional Category Bioactive
Superfamily Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta Binder Superfamily 2
Class Class 712

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 13 100
5-hydroxytryptamine receptor 6 ligand AGN-PC-0BIUF2 family 25 11
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
5-hydroxytryptamine receptor 6 ligand 3-(benzenesulfonyl)-N,5-... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 1
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Casein kinase II subunit alpha inhibitor AGN-PC-0766PM family 4 0
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Cyclin-dependent kinase 2 and MAP kinase-activated protein kin... 3 0
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 9 0
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-(1,2,4-triazol... 2 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-b]pyridazine d... 2 1
Muscarinic acetylcholine receptor M1 and Cytochrome P450 2C9 l... 2 5
Prostaglandin G/H synthase 2 and Cyclooxygenase 2 inhibitor Su... 2 6
Glucocorticoid receptor ligand N-ethyl-4-fluoro-N-[3,3,3-trifl... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00384900 CHEMBL178179 Bioactive AGN-PC-046PXY
CFAMM00384897 CHEMBL360573 Bioactive SureCN14427569

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26233 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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