CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8029
Family Name Histamine H3 receptor ligand SureCN2784769 family
No. of Seeds 12 No. of Other Members 2
Family Centroid CFAMM00384926 Functional Category Bioactive
Superfamily Histamine H3 receptor and Prolyl endopeptidase Binder Superfamily
Class Class 769

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Histamine H3 receptor Ligand ABT-239 Family 8 20
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
Histamine H3 receptor Ligand A-349821 Family 49 228
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 4 18
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 62
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 2 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 20 9
Histamine H3 receptor ligand SureCN2786002 family 8 3
Histamine H3 receptor ligand SureCN2785624 family 2 0
Histamine H3 receptor ligand SureCN2785131 family 7 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Sigma no... 2 4
Histamine H3 receptor ligand 2-(3,3-difluoropyrrolidin-1-yl)-1... 2 0
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-074... 5 4
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 2 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 3 9
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0


External ID

Functional Category

Molecule Name

CFAMM00384929 CHEMBL426603 Bioactive SureCN2785650
CFAMM00384916 CHEMBL179539 Bioactive SureCN2787562
CFAMM00384923 CHEMBL178682 Bioactive SureCN2785210
CFAMM00384928 CHEMBL179263 Bioactive SureCN2787132
CFAMM00384927 CHEMBL368699 Bioactive SureCN2787519
CFAMM00384926 CHEMBL178192 Bioactive SureCN2784769
CFAMM00384919 CHEMBL362607 Bioactive SureCN2784949
CFAMM00384918 CHEMBL362662 Bioactive SureCN2784779
CFAMM00384925 CHEMBL2031738 Bioactive (4-fluoranylphenyl)-[2-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]-1-benzofuran-5-yl]methanone
CFAMM00384917 CHEMBL179372 Bioactive SureCN2787168
CFAMM00384924 CHEMBL178410 Bioactive SureCN2784850

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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