CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8041
Family Name Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(methyl)sulfamoyl]amino]-2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine family
No. of Seeds 17 No. of Other Members 2
Family Centroid CFAMM00385016 Functional Category Bioactive
Superfamily Hepatocyte growth factor receptor Ligand MK-8033 Superfamily
Class Class 845

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Hepatocyte growth factor receptor Ligand MK-8033 Family 19 42
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Interleukin-1 beta and Interleukin-6 Inhibitor Ibudilast Family 2 11
D(3) dopamine receptor Ligand SB-277011 Family 13 178
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Potassium voltage-gated channel subfamily H member 2 Ligand E-... 1 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 4
Cannabinoid receptor 2 Ligand JWH-249 Family 7 13
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Adenosine receptor A3 Ligand 2-phenyl-2h-pyrazolo[4,3-d]pyrimi... 2 7
DNA topoisomerase 2-beta Inhibitor 2-(2-hydroxyethyl)anthra[1,... 2 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 29
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Metabotropic glutamate receptor 1 ligand GTPL6334 family 6 4
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Hepatocyte growth factor receptor ligand N-(11-oxo-2-thiophen-... 1 1
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
Type-1 angiotensin II receptor ligand 2-[[(5-ethylpyrazolo[1,5... 1 0
Hepatocyte growth factor receptor ligand N-[2-(1,4-dioxa-8-aza... 1 0
Hepatocyte growth factor receptor ligand N-[2-(3-chlorophenyl)... 2 2
Hepatocyte growth factor receptor ligand 1-methyl-N-[2-(1-meth... 1 0
Hepatocyte growth factor receptor and Macrophage-stimulating p... 1 0
Steroid hormone receptor ERR1 ligand methyl 3-[4-(2-aminobenzo... 4 2
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 7 2
G1/S-specific cyclin-E2 and G1/S-specific cyclin-E1 inhibitor ... 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 5 9


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00385017 CHEMBL1802912 Bioactive 3-fluoro-N-[2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridin-9-yl]azetidine-1-sulfonamide
CFAMM00385010 CHEMBL1802835 Bioactive 9-(dimethylsulfamoylamino)-2-[1-(2-fluoro-3-hydroxypropyl)pyrazol-4-yl]-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine
CFAMM00385016 CHEMBL1802913 Bioactive 9-[[3-methoxypropyl(methyl)sulfamoyl]amino]-2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine
CFAMM00385009 CHEMBL1802834 Bioactive 9-(dimethylsulfamoylamino)-2-[1-(2-fluoroethyl)pyrazol-4-yl]-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine
CFAMM00385015 CHEMBL1802914 Bioactive 9-[[methyl-[(3S)-oxolan-3-yl]sulfamoyl]amino]-2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine
CFAMM00385008 CHEMBL1802833 Bioactive 9-(dimethylsulfamoylamino)-2-[1-(3-hydroxypropyl)pyrazol-4-yl]-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine
CFAMM00385014 CHEMBL1802917 Bioactive 9-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-11-oxo-2-(1-piperidin-4-ylpyrazol-4-yl)benzo[1,2]cyclohepta[2,4-b]pyridine
CFAMM00385007 CHEMBL1802832 Bioactive 2-[1-[3-(dimethylamino)propyl]pyrazol-4-yl]-9-(dimethylsulfamoylamino)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine
CFAMM00385020 CHEMBL1802906 Bioactive 2-(1-methylpyrazol-4-yl)-11-oxo-9-(sulfamoylamino)benzo[1,2]cyclohepta[2,4-b]pyridine
CFAMM00385013 CHEMBL1802603 Bioactive 9-amino-2-(1-methylpyrazol-4-yl)benzo[1,2]cyclohepta[2,4-b]pyridin-11-one
CFAMM00385006 CHEMBL1802831 Bioactive 4-[2-[4-[9-(dimethylsulfamoylamino)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridin-2-yl]pyrazol-1-yl]acetyl]morpholine
CFAMM00385019 CHEMBL1802903 Bioactive 9-(dimethylsulfamoylamino)-2-[1-(2-fluoro-3-pyrrolidin-1-ylpropyl)pyrazol-4-yl]-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine
CFAMM00385012 CHEMBL1802605 Bioactive 9-(methylamino)-2-(1-methylpyrazol-4-yl)benzo[1,2]cyclohepta[2,4-b]pyridin-11-one
CFAMM00385005 CHEMBL1782649 Bioactive 8-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine
CFAMM00385018 CHEMBL1802911 Bioactive N-[2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridin-9-yl]azetidine-1-sulfonamide
CFAMM00385011 CHEMBL1802836 Bioactive 9-(dimethylsulfamoylamino)-2-[1-(2-fluoro-3-methoxypropyl)pyrazol-4-yl]-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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