CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8053
Family Name Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7WD family
No. of Seeds 7 No. of Other Members 3
Family Centroid CFAMM00385065 Functional Category Bioactive with Natural Product
Superfamily Cholinesterase and Androgen receptor Binder Superfamily
Class Class 770

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Histamine N-methyltransferase inhibitor aminoquinoline Amodiaq... 8 23
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Food vacuoles Inhibitor Mefloquine Family 2 25
DNA Binder Elliptinium Acetate Family 11 116
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Citric Acid family 2 58
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cytochrome b Inhibitor 2-nonyl-4-hydroxyquinoline N-OXIDE Family 2 22
Acetylcholinesterase Inhibitor Velnacrine Family 2 29
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Oestrogen receptor and Estrogen receptor beta Ligand ZK-119010... 2 16
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
E3 ubiquitin-protein ligase Mdm2 Inhibitor NSC-66811 Family 4 27
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
D(1B) dopamine receptor and D(2) dopamine receptor Ligand Flut... 1 6
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9
Metabotropic glutamate receptor 5 Ligand 3-hydroxy-5-(2-methyl... 2 1
Metabotropic glutamate receptor 5 Ligand (3-(2-methylquinolin-... 3 6
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 1
Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658... 8 54
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YQD... 1 5
Kinesin-like protein KIF11 inhibitor AGN-PC-080PZM family 1 11
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-0886S... 1 18
Glucocorticoid receptor ligand 4-fluoro-2-[5,5,5-trifluoro-4-h... 3 9
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 30
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
Adenosine receptor A1 and Adenosine receptor A2a ligand (6E)-6... 2 2
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Methionine--tRNA ligase, cytoplasmic and Methionine--tRNA liga... 8 6
Methionine--tRNA ligase inhibitor 2-({3-[(3,5-Dichlorobenzyl)a... 5 7
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
Androgen receptor ligand (6R,7S)-6-ethyl-7-methyl-4-(trifluoro... 22 29
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 5 8
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Cholinesterase and Acetylcholinesterase inhibitor 6-[2-methoxy... 12 6
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Transient receptor potential cation channel subfamily V member... 1 5
Estrogen receptor beta and Estrogen receptor ligand 2-fluoro-4... 1 0
5-hydroxytryptamine receptor 2A ligand (3R,4R)-3-(2-phenyl-1H-... 1 18
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Estrogen receptor and Estrogen receptor beta ligand SureCN6841... 2 5
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PJ... 4 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 18 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Serine/threonine-protein kinase Chk2 inhibitor (6E)-4-fluoro-6... 3 6
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 2 8
Fatty acid synthase inhibitor SureCN4564627 family 1 2
DNA topoisomerase 2-alpha and DNA topoisomerase 2-beta inhibit... 2 7
Kinesin-like protein KIF11 inhibitor AGN-PC-07R5ZC family 1 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00385068 CHEMBL2147359 Bioactive 2-[[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptylamino]methyl]phenol
CFAMM00385067 CHEMBL1783194 Bioactive AGN-PC-09Q7WA
CFAMM00385065 CHEMBL1783239 Bioactive AGN-PC-09Q7WD
CFAMM00385063 CHEMBL2147360 Bioactive 2-[[9-(1,2,3,4-tetrahydroacridin-9-ylamino)nonylamino]methyl]phenol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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