CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8054
Family Name Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-aminobutyric acid receptor subunit beta-3 ligand 9-amino-5-(2,2-dimethylpropyl)-2-propyl-3H-pyrrolo[3,4-b]quinolin-1-one family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00385069 Functional Category Bioactive
Superfamily Poly [ADP-ribose] polymerase 1 Binder Superfamily 4
Class Class 1078

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Setipiprant family 5 118
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Poly [ADP-ribose] polymerase 1 Inhibitor 2-ethylquinoline-8-ca... 3 4
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 1-(3-(2-methylquinoli... 2 12
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 4 21
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 3A ligand SureCN8035577 family 5 4
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Translocator protein inhibitor AGN-PC-08WI0V family 1 0
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 4 2
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Translocator protein inhibitor N,N-diethyl-11-(2-fluoroethyl)-... 14 9
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 14 1
Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-... 2 14
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Neuromedin-K receptor and Potassium voltage-gated channel subf... 13 2
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Motilin receptor ligand SureCN2768052 family 3 0
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Neuromedin-K receptor ligand SureCN3894466 family 1 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Translocator protein inhibitor 2-(7-Chloro-5-methyl-4-oxo-3-ph... 1 0
Histamine H3 receptor ligand SureCN3542210 family 1 0
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Heat shock protein HSP 90-alpha inhibitor CHEMBL1760611 family 19 25
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Acetylcholinesterase inhibitor (9R)-11-amino-6,6,9-trimethyl-9... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00385069 CHEMBL1783244 Bioactive 9-amino-5-(2,2-dimethylpropyl)-2-propyl-3H-pyrrolo[3,4-b]quinolin-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26822 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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