CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8057
Family Name Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-aminobutyric acid receptor subunit beta-3 ligand 9-amino-2-cyclobutyl-5-(2,5-dimethoxyphenyl)-3H-pyrrolo[3,4-b]quinolin-1-one family
No. of Seeds 2 No. of Other Members 5
Family Centroid CFAMM00385105 Functional Category Bioactive with Natural Product
Superfamily Renin and Gamma-aminobutyric acid receptor subunit beta-3 Binder Superfamily
Class Class 297

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Integrin beta-3 Inhibitor L-756568 Family 8 59
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Renin inhibitor AGN-PC-09M9MJ family 2 23
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 12
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
NS5B protein inhibitor AC1O5AET family 3 1
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 7-met... 3 2
Cannabinoid receptor 1 ligand AGN-PC-0766FR family 4 3
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 7-met... 2 1
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Signal transducer and activator of transcription 1-alpha/beta ... 1 36


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00385100 CHEMBL1783276 Bioactive 9-amino-2-cyclobutyl-5-(2,5-dimethoxyphenyl)-6-fluoro-3H-pyrrolo[3,4-b]quinolin-1-one
CFAMM00385105 CHEMBL1783269 Bioactive 9-amino-2-cyclobutyl-5-(2,5-dimethoxyphenyl)-3H-pyrrolo[3,4-b]quinolin-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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