CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8058
Family Name Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-aminobutyric acid receptor subunit beta-3 ligand 4-amino-8-(4-methoxypyridin-3-yl)-N-propylcinnoline-3-carboxamide family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00385106 Functional Category Bioactive with Natural Product
Superfamily Coagulation factor X Inhibitor Apixaban Superfamily
Class Class 999

Cousin Family NamesSeedsMembers
Mitogen-activated protein kinase 12 Inhibitor ARRY-797 Family 13 41
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK2... 15 18
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 5 0
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-(cy... 3 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 0
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Vascular endothelial growth factor receptor 2 and Vascular end... 2 3
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00385108 CHEMBL1783279 Bioactive 4-amino-8-(2,4-dimethoxypyrimidin-5-yl)-N-propylcinnoline-3-carboxamide
CFAMM00385107 CHEMBL1783286 Bioactive 4-amino-N-cyclopropyl-8-(2-methoxy-5-methylpyridin-3-yl)cinnoline-3-carboxamide
CFAMM00385106 CHEMBL1783280 Bioactive 4-amino-8-(4-methoxypyridin-3-yl)-N-propylcinnoline-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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