CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8079
Family Name Neuropeptide Y receptor type 5 ligand (5E)-5-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methylimidazolidin-2-ylidene]pyridin-2-one family
No. of Seeds 18 No. of Other Members 3
Family Centroid CFAMM00385342 Functional Category Bioactive
Superfamily Beta-secretase 1 and Beta-secretase 2 Binder Superfamily 5
Class Class 840

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Cyclin-dependent kinase 8 Inhibitor Oxindole 94 Family 2 3
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Prothrombin inhibitor SureCN5855286 family 15 8
Prothrombin inhibitor SureCN7371121 family 13 3
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor 2-[6-chloro-3-[(2,2-difluoro-2-pyridin-2... 5 0
Cathepsin K inhibitor SureCN2155973 family 3 1
Gonadotropin-releasing hormone receptor ligand AGN-PC-075KV1 f... 4 1
Prothrombin and Trypsin-1 inhibitor SureCN12636557 family 9 1
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Prothrombin inhibitor AGN-PC-09QKE4 family 1 0
Prostaglandin E synthase inhibitor AGN-PC-09QHBK family 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 5
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Beta-secretase 1 and Beta-secretase 2 inhibitor 5-[(1R)-3-amin... 8 1
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 3 2
Prothrombin inhibitor AGN-PC-073GVF family 12 1
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN4964150 ... 3 0
Neuropeptide Y receptor type 5 ligand SureCN4477700 family 1 0
Neuropeptide Y receptor type 5 and Potassium voltage-gated cha... 1 0
Mitogen-activated protein kinase 14 inhibitor 4-(4-fluoropheny... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00385334 CHEMBL1784127 Bioactive SureCN3160182
CFAMM00385347 CHEMBL1783927 Bioactive SureCN5953808
CFAMM00385333 CHEMBL1784124 Bioactive (5E)-3-chloro-5-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methylimidazolidin-2-ylidene]pyridin-2-one
CFAMM00385339 CHEMBL489726 Bioactive SureCN4468152
CFAMM00385332 CHEMBL1784125 Bioactive (5E)-5-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methylimidazolidin-2-ylidene]-3-(trifluoromethyl)pyridin-2-one
CFAMM00385346 CHEMBL1783926 Bioactive SureCN5953976
CFAMM00385338 CHEMBL1784128 Bioactive SureCN3169762
CFAMM00385330 CHEMBL1784130 Bioactive SureCN3154436
CFAMM00385345 CHEMBL1784119 Bioactive 1-ethoxy-5-[(4S,5S)-5-(4-fluorophenyl)-5-(6-fluoropyridin-3-yl)-4-methyl-1,4-dihydroimidazol-2-yl]pyridin-2-one
CFAMM00385337 CHEMBL1784129 Bioactive SureCN3154478
CFAMM00385351 CHEMBL1784131 Bioactive SureCN3159162
CFAMM00385344 CHEMBL1783924 Bioactive 6-[(4S,5S)-5-(4-fluorophenyl)-5-(6-fluoropyridin-3-yl)-4-methyl-1,4-dihydroimidazol-2-yl]-4-methyl-1H-pyridin-2-one
CFAMM00385336 CHEMBL1784120 Bioactive (5E)-5-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methylimidazolidin-2-ylidene]-3-methylpyridin-2-one
CFAMM00385350 CHEMBL1784133 Bioactive SureCN3161275
CFAMM00385343 CHEMBL1783923 Bioactive SureCN5953820
CFAMM00385335 CHEMBL1784126 Bioactive (5E)-5-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methylimidazolidin-2-ylidene]-3-methoxypyridin-2-one
CFAMM00385349 CHEMBL1784132 Bioactive SureCN3154533
CFAMM00385342 CHEMBL1783920 Bioactive (5E)-5-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methylimidazolidin-2-ylidene]pyridin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27276 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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