CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8130
Family Name Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-3 beta inhibitor AGN-PC-075C7I family
No. of Seeds 7 No. of Other Members 1
Family Centroid CFAMM00385782 Functional Category Bioactive
Superfamily Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 Binder Superfamily
Class Class 2498

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 11
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 8 12
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 11 11
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 0
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 4 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Glycogen synthase kinase-3 beta inhibitor bip-135 family 3 1
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 6 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Sodium-dependent serotonin transporter inhibitor SureCN5477150... 4 1
Vascular endothelial growth factor receptor 2 ligand (4Z)-4-[(... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00385782 CHEMBL361996 Bioactive AGN-PC-075C7I
CFAMM00385781 CHEMBL359871 Bioactive AGN-PC-075C6T
CFAMM00385780 CHEMBL178820 Bioactive AGN-PC-075C5P
CFAMM00385778 CHEMBL2386088 Bioactive CHEMBL2386088
CFAMM00385784 CHEMBL361765 Bioactive AGN-PC-075C6H
CFAMM00385783 CHEMBL178850 Bioactive AGN-PC-075C7T

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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