CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8132
Family Name Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benzodipyrazole deriv. 7r family
No. of Seeds 3 No. of Other Members 5
Family Centroid CFAMM00385806 Functional Category Bioactive
Superfamily Cyclin-A2 and Cyclin-dependent kinase 2 Binder Superfamily 3
Class Class 1276

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
NF-kappa-B and Protein kinase C zeta type Inhibitor Go6976 Family 9 71
Vascular endothelial growth factor receptor 2 Ligand Isoindoli... 11 36
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Vascular endothelial growth factor receptor 2 and Angiopoietin... 4 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 1 4
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 1 7
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor SBC family 5 18
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-075CD... 2 8
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Mitogen-activated protein kinase 1 inhibitor Pyrrole Carboxami... 3 12
Angiopoietin-1 receptor and Vascular endothelial growth factor... 9 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 2
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
Rho-associated protein kinase 2 inhibitor 2-[(3S,4R)-4-(4-fluo... 9 0
Platelet-derived growth factor receptor beta and Ribosomal pro... 1 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00385800 CHEMBL178827 Bioactive dihydro-benzodipyrazole deriv. 7k
CFAMM00385807 CHEMBL179588 Bioactive dihydro-benzodipyrazole deriv. 7o
CFAMM00385806 CHEMBL554716 Bioactive dihydro-benzodipyrazole deriv. 7r

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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