CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8136
Family Name Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 family
No. of Seeds 11 No. of Other Members 10
Family Centroid CFAMM00385830 Functional Category Bioactive
Superfamily Tryptophan 5-hydroxylase 1 and Integrin beta-5 Binder Superfamily
Class Class 2020

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Arachidonate 5-lipoxygenase Inhibitor MK-591 Family 9 161
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Tivozanib family 4 6
SB1518 family 7 103
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 10 54
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Integrin beta-3 and Integrin alpha-V inhibitor (3S,7S)-7-hydro... 5 1
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2489170 f... 8 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Platelet-derived growth factor receptor beta and Macrophage co... 7 0
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(4-fluo... 7 1
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Hepatocyte growth factor receptor and Vascular endothelial gro... 15 0
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... 1 0
Integrin beta-3 and Integrin alpha-V inhibitor SureCN6223678 f... 14 1
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Integrin beta-3 and Integrin alpha-V inhibitor SureCN6220269 f... 1 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 1 1
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 1 0
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-03OERH f... 1 0
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Diacylglycerol O-acyltransferase 1 inhibitor 4-[5-[5-(1H-benzi... 7 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
Peroxisome proliferator-activated receptor gamma and Cytochrom... 1 1
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Peroxisome proliferator-activated receptor gamma ligand (2S)-2... 8 0
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 1
Fatty-acid amide hydrolase 1 inhibitor bisarylimidazole deriva... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00385833 CHEMBL193269 Bioactive SureCN2489240
CFAMM00385839 CHEMBL178859 Bioactive SureCN12210499
CFAMM00385826 CHEMBL189053 Bioactive SureCN2491759
CFAMM00385832 CHEMBL365577 Bioactive SureCN852492
CFAMM00385824 CHEMBL193189 Bioactive SureCN2490010
CFAMM00385830 CHEMBL372443 Bioactive SureCN2491273
CFAMM00385823 CHEMBL192698 Bioactive AGN-PC-075IMG
CFAMM00385842 CHEMBL190625 Bioactive SureCN2488575
CFAMM00385828 CHEMBL192879 Bioactive SureCN2490589
CFAMM00385841 CHEMBL189255 Bioactive SureCN2491160
CFAMM00385834 CHEMBL190309 Bioactive SureCN2488561

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26235 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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