CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8144
Family Name Pol polyprotein inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-N-[(2S,3R)-3-hydroxy-1-[methyl(pyridin-2-yl)amino]-1-oxobutan-2-yl]-5-[[(2S)-3-methyl-2-[(2-naphthalen-1-yloxyacetyl)amino]butanoyl]amino]-2-propan-2-ylhexanamide family
No. of Seeds 7 No. of Other Members 3
Family Centroid CFAMM00385885 Functional Category Bioactive
Superfamily Pol polyprotein and Renin Binder Superfamily
Class Class 850

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Indinavir Family 36 211
Renin Inhibitor Enalkiren Family 56 44
Plasmepsin-2 Inhibitor KNI-10526 Family 8 10
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Pol polyprotein and Renin inhibitor U-75875 family 12 1
Pol polyprotein inhibitor N-[(3R,4R,5R)-5-[[(2S)-1-(1H-benzimi... 5 4
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[5-methy... 4 5
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 4
Integrin beta-1 and Integrin alpha-5 inhibitor SureCN14453479 ... 3 5
Pol polyprotein inhibitor Palinavir deriv. 13 family 1 0
Renin inhibitor SureCN7300793 family 2 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00385885 CHEMBL2304002 Bioactive (2S,4S,5S)-6-cyclohexyl-4-hydroxy-N-[(2S,3R)-3-hydroxy-1-[methyl(pyridin-2-yl)amino]-1-oxobutan-2-yl]-5-[[(2S)-3-methyl-2-[(2-naphthalen-1-yloxyacetyl)amino]butanoyl]amino]-2-propan-2-ylhexanamide
CFAMM00385884 CHEMBL2304003 Bioactive (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S,3R)-3-hydroxy-2-[(2-naphthalen-1-yloxyacetyl)amino]butanoyl]amino]-N-[(2S,3S)-3-methyl-1-[methyl(pyridin-2-yl)amino]-1-oxopentan-2-yl]-2-propan-2-ylhexanamide
CFAMM00385882 CHEMBL1790062 Bioactive (3R)-4-[[(2S,5S)-1-cyclohexyl-3-hydroxy-6-methyl-5-[[(2S,3R)-3-methyl-1-[methyl(pyridin-2-yl)amino]-1-oxopentan-2-yl]carbamoyl]heptan-2-yl]amino]-4-oxo-3-[(2-phenoxyacetyl)amino]butanoic acid
CFAMM00385881 CHEMBL1790066 Bioactive 2-hydroxy-3-[[(4S,7S)-5-hydroxy-2,8-dimethyl-7-[[(2S,3R)-3-methyl-1-[methyl(pyridin-2-yl)amino]-1-oxopentan-2-yl]carbamoyl]nonan-4-yl]carbamoyl]-4-oxo-5-phenoxypentanoic acid
CFAMM00385887 CHEMBL2304047 Bioactive (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-3-hydroxy-2-[(2-naphthalen-1-yloxyacetyl)amino]propanoyl]amino]-N-[(2S,3S)-3-methyl-1-[methyl(pyridin-2-yl)amino]-1-oxopentan-2-yl]-2-propan-2-ylhexanamide
CFAMM00385880 CHEMBL1790064 Bioactive (3R)-4-[[(4S,7S)-5-hydroxy-2,8-dimethyl-7-[[(2S,3R)-3-methyl-1-[methyl(pyridin-2-yl)amino]-1-oxopentan-2-yl]carbamoyl]nonan-4-yl]amino]-4-oxo-3-[(2-phenoxyacetyl)amino]butanoic acid
CFAMM00385886 CHEMBL2304049 Bioactive (2S,4S,5S)-6-cyclohexyl-4-hydroxy-N-[(2S)-3-hydroxy-1-[methyl(pyridin-2-yl)amino]-1-oxopropan-2-yl]-5-[[(2S)-3-methyl-2-[(2-naphthalen-1-yloxyacetyl)amino]butanoyl]amino]-2-propan-2-ylhexanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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