CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8145
Family Name Renin inhibitor (3R)-4-[[(2S,5S)-1-cyclohexyl-3-hydroxy-6-methyl-5-[[(2S,3R)-3-methyl-1-[methyl(pyridin-2-yl)amino]-1-oxopentan-2-yl]carbamoyl]heptan-2-yl]amino]-4-oxo-3-[(2-phenylacetyl)amino]butanoic acid family
No. of Seeds 3 No. of Other Members 4
Family Centroid CFAMM00385893 Functional Category Bioactive
Superfamily Renin and C-C chemokine receptor type 5 Binder Superfamily
Class Class 1170

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
HIV-1 protease Inhibitor Atazanavir Family 16 58
Renin Inhibitor Remikiren Family 100 126
CP-18770 family 6 27
Lethal factor Inhibitor GM6001 Family 50 435
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Pol polyprotein inhibitor (2S)-N-[(2S,4S,5S)-4-hydroxy-5-[[(2S... 1 3
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
Pol polyprotein inhibitor AC1LAD48 family 19 5
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Renin and Cathepsin D inhibitor tert-butyl N-[(2R)-1-[[3-[[(2R... 19 4
Renin and Pepsin A inhibitor tert-butyl N-[(2S)-1-[[2-[[(4S,5S... 4 0
Integrin alpha-V and Integrin beta-5 inhibitor SureCN6563167 f... 2 10
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[6-m... 13 12
Renin inhibitor propan-2-yl (3R)-2-hydroxy-3-[[(2S)-3-(1H-imid... 4 0
C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl... 10 4
Pol polyprotein and Renin inhibitor U-75875 family 12 1
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Pol polyprotein inhibitor (2R,3R,4R,5S)-5-[[(2S)-2-[5-[(4R,6aS... 1 0
B1 bradykinin receptor ligand AGN-PC-005XAO family 3 17
B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[[... 22 11
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Renin inhibitor (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-d... 3 0
Renin inhibitor (2S)-N-[(2S,3S)-1-cyclohexyl-3-hydroxy-5-(3-im... 4 0
Pol polyprotein inhibitor 183854-98-0 family 15 2
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(3-fluor... 10 0
Renin inhibitor tert-butyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl-3,4... 2 2
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 6 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-3-[... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00385888 CHEMBL1790067 Bioactive 2-hydroxy-3-[[(4S,7S)-5-hydroxy-2,8-dimethyl-7-[[(2S,3R)-3-methyl-1-[methyl(pyridin-2-yl)amino]-1-oxopentan-2-yl]carbamoyl]nonan-4-yl]carbamoyl]-4-oxo-5-phenylpentanoic acid
CFAMM00385894 CHEMBL1790076 Bioactive (3R)-4-[[(4S,7S)-5-hydroxy-2,8-dimethyl-7-[[(2S,3R)-3-methyl-1-[methyl(pyridin-2-yl)amino]-1-oxopentan-2-yl]carbamoyl]nonan-4-yl]amino]-4-oxo-3-[(2-phenylacetyl)amino]butanoic acid
CFAMM00385893 CHEMBL1790070 Bioactive (3R)-4-[[(2S,5S)-1-cyclohexyl-3-hydroxy-6-methyl-5-[[(2S,3R)-3-methyl-1-[methyl(pyridin-2-yl)amino]-1-oxopentan-2-yl]carbamoyl]heptan-2-yl]amino]-4-oxo-3-[(2-phenylacetyl)amino]butanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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