CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8163
Family Name Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S,9S,12R)-3-[(2R)-butan-2-yl]-6-(1-methyl-4-oxoquinolin-3-yl)-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone family
No. of Seeds 2 No. of Other Members 4
Family Centroid CFAMM00296211 Functional Category Bioactive with Natural Product
Superfamily Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S,9S,12R)-3-[(2R)-butan-2-yl]-6-(1-methyl-4-oxoquinolin-3-yl)-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone Superfamily
Class Class 664

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Integrin alpha-4 Inhibitor R1295 Family 18 59
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
K-604 family 4 71
Amonafide family 3 35
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Fumarate reductase flavoprotein subunit Inhibitor 2-heptyl-4-h... 3 16
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Integrin beta-3 Inhibitor SB-208651 Family 9 28
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 4 8
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 5 13
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 1-eth... 7 3
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 53
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Peptide deformylase inhibitor (2R)-2-(cyclopentylmethyl)-N-[(2... 5 1
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 8 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-cyc... 2 1
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Cannabinoid receptor 2 ligand AGN-PC-00SRU8 family 1 3
Cannabinoid receptor 2 ligand AGN-PC-046LZ0 family 1 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 2
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Protein farnesyltransferase subunit beta and Protein farnesylt... 4 13
Multidrug resistance protein 1 inhibitor AGN-PC-07R6HU family 1 0
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 12
3-prop-2-enyl-1H-quinolin-4-one NP 6-amino-2-methylquinolin-4-... 5 3


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27515 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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