CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8173
Family Name D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E)-4-[4-(2,3-dichlorophenyl)piperazin-1-yl]but-2-enyl]-4-(1H-imidazol-2-yl)benzamide family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00386049 Functional Category Bioactive
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Binder Superfamily 13
Class Class 2337

Cousin Family NamesSeedsMembers
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
JAK Inhibitor Momelotinib Family 33 83
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Histamine H3 receptor Ligand SCH79687 Family 11 29
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Lysosomal Pro-X carboxypeptidase inhibitor 2-amino-N-[(2S)-1-[... 11 16
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Lysosomal Pro-X carboxypeptidase inhibitor 1-[(2S)-2-(5,6-dich... 2 2
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Cell division cycle 7-related protein kinase and Dual specific... 3 1
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN9931311 family 2 0
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-[5-(6-chl... 2 0
Substance-K receptor ligand SureCN9035669 family 10 5
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R96X family 7 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00386049 CHEMBL179351 Bioactive N-[(E)-4-[4-(2,3-dichlorophenyl)piperazin-1-yl]but-2-enyl]-4-(1H-imidazol-2-yl)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26831 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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