CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8185
Family Name Serine/threonine-protein kinase B-raf inhibitor furan-based compound, 15 family
No. of Seeds 6 No. of Other Members 3
Family Centroid CFAMM00386120 Functional Category Bioactive
Superfamily Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-yl)-1-methyl-1h-indole Superfamily
Class Class 656

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Cathepsin K Inhibitor Relacatib Family 26 32
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
5-hydroxytryptamine receptor 3A and Neuronal acetylcholine rec... 1 3
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Pol polyprotein inhibitor AC1LARNY family 28 17
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 6 9
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 8 12
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
Cytochrome P450 2C19 and Inositol monophosphatase 1 inhibitor ... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
Histamine H3 receptor ligand SureCN2784306 family 5 3
MAP kinase-activated protein kinase 2 inhibitor 5-(4-cyanophen... 3 8
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-(1-hydrox... 1 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
MAP kinase-activated protein kinase 2 inhibitor 4-[5-[[2-(2-me... 3 4
MAP kinase-activated protein kinase 2 inhibitor 4-[4-oxo-8-pip... 4 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Macrophage colony-stimulating factor 1 receptor ligand 5-cyano... 1 0
Cathepsin K and Cathepsin L1 inhibitor AC1NR9VX family 2 2
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-073HN6 f... 1 1
Substance-P receptor ligand SureCN2139814 family 7 7
Cannabinoid receptor 1 ligand (4-hydroxynaphthalen-1-yl)-[1-(2... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 1
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
CGMP-dependent protein kinase inhibitor AGN-PC-075IHL family 2 8
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Collagenase 3 inhibitor SureCN1316041 family 4 3
DNA-dependent protein kinase catalytic subunit inhibitor 2-mor... 1 4
Arachidonate 5-lipoxygenase inhibitor 4-(furan-3-yl)-7-[[5-(4-... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00386122 CHEMBL514210 Bioactive furan-based compound, 16
CFAMM00386121 CHEMBL477149 Bioactive furan-based compound, 14
CFAMM00386120 CHEMBL515796 Bioactive furan-based compound, 15
CFAMM00386119 CHEMBL1794072 Bioactive SB-682330-A
CFAMM00386125 CHEMBL476732 Bioactive 4-[[(4E)-4-(1-nitroso-2,3-dihydroinden-5-ylidene)-5-(1H-pyridin-4-ylidene)furan-2-yl]methyl]morpholine
CFAMM00386124 CHEMBL1964266 Bioactive furan-based compound, 12

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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