CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8198
Family Name Cytochrome P450 26A1 and Cytochrome P450 3A4 inhibitor 3-[6-[(1R,2R)-2-(dimethylamino)-1-imidazol-1-ylbutyl]naphthalen-2-yl]oxy-2,2-dimethylpropanoic acid family
No. of Seeds 14 No. of Other Members 26
Family Centroid CFAMM00386209 Functional Category Bioactive
Superfamily Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor Rac-4'-(1-imidazol-1-yl-propyl)-biphenyl-3-ol Superfamily
Class Class 1096

Cousin Family NamesSeedsMembers
Thromboxane-A synthase Inhibitor Dazoxiben Family 2 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 1 14
Aromatase Inhibitor 3-((1h-imidazol-1-yl)methyl)-9h-xanthen-9-... 6 17
Aromatase Inhibitor 5-bromo-8-imidazol-1-ylmethyl-chromen-4-on... 2 0
Aromatase Inhibitor 1-(7-methoxy-2-phenyl-chroman-4-yl)-1h-imi... 2 22
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 1-... 2 9
Aromatase Inhibitor 4'-cyano-3-(imidazolylmethyl)flavone Family 4 3
Aromatase Inhibitor 4-((1h-imidazol-1-yl)methyl)-2h-chromen-2-... 3 69
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor Rac-4'-(1-i... 5 9
Aromatase Inhibitor 1-(4-nitro-2-phenoxybenzyl)-1h-imidazole F... 1 4
Protein farnesyltransferase subunit beta Inhibitor A-313326 Fa... 85 149
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
Thromboxane A2 receptor ligand SureCN9045130 family 4 32
Thromboxane A2 receptor ligand AC1NSKJR family 13 42
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 10 54
Aromatase inhibitor AGN-PC-075MOK family 1 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 8 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 3
Thromboxane A2 receptor ligand SureCN9046307 family 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Aromatase inhibitor 4-[(Z)-1-(3,5-dimethoxyphenyl)-3-imidazol-... 1 2
Delta-type opioid receptor and Kappa-type opioid receptor liga... 2 0
Thromboxane-A synthase inhibitor AGN-PC-00NE9O family 4 1
Thromboxane-A synthase inhibitor ethyl 4-[[2-[(4-ethoxycarbony... 1 5


External ID

Functional Category

Molecule Name

CFAMM00386235 CHEMBL207486 Bioactive 3-[6-[(1R,2R)-1-imidazol-1-yl-2-[methyl(propan-2-yl)amino]propyl]naphthalen-2-yl]oxy-2,2-dimethylpropanoic acid
CFAMM00386196 CHEMBL179550 Bioactive AGN-PC-075CRJ
CFAMM00386228 CHEMBL180348 Bioactive 2-[4-[[6-[2-(dimethylamino)-1-imidazol-1-ylpropyl]naphthalen-2-yl]oxymethyl]phenyl]acetic acid
CFAMM00386234 CHEMBL368448 Bioactive AGN-PC-00FESI
CFAMM00386206 CHEMBL207304 Bioactive 1-[[6-[(1R,2R)-1-imidazol-1-yl-2-[methyl(propan-2-yl)amino]propyl]naphthalen-2-yl]oxymethyl]cyclopentane-1-carboxylic acid
CFAMM00386233 CHEMBL207942 Bioactive 1-[[6-[(1R,2R)-2-[ethyl(methyl)amino]-1-imidazol-1-ylpropyl]naphthalen-2-yl]oxymethyl]cyclopentane-1-carboxylic acid
CFAMM00386200 CHEMBL377177 Bioactive 1-[[6-[(1R,2R)-2-(dimethylamino)-1-imidazol-1-ylpropyl]naphthalen-2-yl]oxymethyl]cyclopentane-1-carboxylic acid
CFAMM00386205 CHEMBL181309 Bioactive AGN-PC-00AKLH
CFAMM00386232 CHEMBL205862 Bioactive 1-[[6-[(1R,2R)-2-(diethylamino)-1-imidazol-1-ylpropyl]naphthalen-2-yl]oxymethyl]cyclopentane-1-carboxylic acid
CFAMM00386210 CHEMBL208155 Bioactive 3-[6-[(1R,2R)-2-(diethylamino)-1-imidazol-1-ylpropyl]naphthalen-2-yl]oxy-2,2-dimethylpropanoic acid
CFAMM00386209 CHEMBL208443 Bioactive 3-[6-[(1R,2R)-2-(dimethylamino)-1-imidazol-1-ylbutyl]naphthalen-2-yl]oxy-2,2-dimethylpropanoic acid
CFAMM00386223 CHEMBL210780 Bioactive 3-[6-[(1R,2R)-2-[ethyl(methyl)amino]-1-imidazol-1-ylpropyl]naphthalen-2-yl]oxy-2,2-dimethylpropanoic acid
CFAMM00386229 CHEMBL426789 Bioactive AGN-PC-004YWP

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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