CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8219
Family Name ALK tyrosine kinase receptor and Insulin receptor ligand N-[(1R,2R)-2-[[5-chloro-2-[(3-ethyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]cyclohexyl]methanesulfonamide family
No. of Seeds 3 No. of Other Members 6
Family Centroid CFAMM00386356 Functional Category Bioactive
Superfamily Insulin receptor and ALK tyrosine kinase receptor Binder Superfamily
Class Class 1334

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 15 457
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase A Inhibitor PF-03814735 Family 2 12
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
ALK tyrosine kinase receptor and Insulin receptor ligand 2-[[5... 1 0
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase TBK1 and 3-phosphoinositide-de... 3 3
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
Transient receptor potential cation channel subfamily V member... 3 2
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Tyrosine-protein kinase ZAP-70 inhibitor AGN-PC-07CO7Z family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00386356 CHEMBL1796244 Bioactive N-[(1R,2R)-2-[[5-chloro-2-[(3-ethyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]cyclohexyl]methanesulfonamide
CFAMM00386355 CHEMBL1796245 Bioactive N-[(1R,2R)-2-[[5-chloro-2-[[3-(2-methoxyethyl)-1,2,4,5-tetrahydro-3-benzazepin-7-yl]amino]pyrimidin-4-yl]amino]cyclohexyl]methanesulfonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26194 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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