CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8244
Family Name Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1OCFVD family
No. of Seeds 5 No. of Other Members 37
Family Centroid CFAMM00386553 Functional Category Bioactive
Superfamily Melanocortin receptor 4 and Melanocortin receptor 5 Binder Superfamily 3
Class Class 3169

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Motilin receptor Ligand GSK962040 Family 30 457
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
Substance-K receptor and Substance-P receptor ligand N-[4-[[4-... 1 4
Prothrombin inhibitor (2S)-N-[[2-(aminomethyl)-5-chlorophenyl]... 5 11
Prothrombin and Coagulation factor X inhibitor (2S)-N-[(4-amin... 2 3
E3 ubiquitin-protein ligase Mdm2 inhibitor (2'R,3R,3'S,5'S)-6-... 17 51
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Melanocortin receptor 4 ligand tert-butyl 4-[(3S)-4-[4-[2-[1-[... 2 6
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 6
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Neuropeptide Y receptor type 5 ligand 2-(6-chloro-3,4-dihydro-... 5 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand 3-[... 18 26
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 7 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 17
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Melanocortin receptor 4 ligand SureCN6183720 family 2 5
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 3 0
Growth hormone secretagogue receptor type 1 ligand N-[4,6-dich... 2 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Coagulation factor X inhibitor SureCN4463987 family 5 0
Melanocortin receptor 4 ligand SureCN4532266 family 8 0
Substance-K receptor and Neuromedin-K receptor ligand SureCN78... 2 4
Neuromedin-K receptor and Substance-K receptor ligand AGN-PC-0... 2 2
Substance-K receptor and Neuromedin-K receptor ligand 1-benzyl... 3 10
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Glutamate receptor ionotropic, NMDA 1 ligand CHEMBL40730 family 4 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
B1 bradykinin receptor ligand 2-[(2R)-1-(3,4-dichlorophenyl)su... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide de... 2 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00386519 CHEMBL181162 Bioactive SureCN4511965
CFAMM00386518 CHEMBL180487 Bioactive (3S)-N-[(2R)-3-(4-chlorophenyl)-1-[4-[2-[methyl(methylsulfonyl)amino]phenyl]piperazin-1-yl]-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
CFAMM00386540 CHEMBL338768 Bioactive (3R)-N-[(2R)-3-(4-chlorophenyl)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
CFAMM00386553 CHEMBL179836 Bioactive AC1OCFVD
CFAMM00386529 CHEMBL368008 Bioactive SureCN4514886

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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