CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8261
Family Name Cannabinoid receptor 2 ligand 2-tert-butyl-5-ethylsulfonyl-1-(oxan-4-ylmethyl)benzimidazole family
No. of Seeds 28 No. of Other Members 32
Family Centroid CFAMM00386735 Functional Category Bioactive
Superfamily Cannabinoid receptor 2 and Prelamin-A/C Binder Superfamily
Class Class 519

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Mizolastine Family 14 603
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 6 60
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Gonadotropin-releasing hormone receptor ligand AGN-PC-009WYJ f... 1 4
Cannabinoid receptor 2 ligand 2-tert-butyl-1-(oxan-4-ylmethyl)... 8 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[[2... 3 0
Complement C1s subcomponent and Coagulation factor X inhibitor... 1 22
Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 ligand ... 8 19
Neuropeptide Y receptor type 5 ligand 1-phenyl-5-[6-(2,2,2-tri... 4 1
C-C chemokine receptor type 2 ligand N-[(1S,2R,4R)-2-(benzenes... 7 9
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Neuropeptide Y receptor type 5 ligand 2-phenyl-4-(6-propylsulf... 12 5
Neuropeptide Y receptor type 5 ligand 2-(2,2-difluoro-2-phenyl... 2 2
Neuropeptide Y receptor type 5 ligand (6-ethylsulfonyl-1H-benz... 1 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Cannabinoid receptor 2 ligand 4-[[2-tert-butyl-1-(cyclohexylme... 2 0
Cannabinoid receptor 2 ligand 4-[2-tert-butyl-1-(oxan-4-ylmeth... 5 0
Nuclear receptor subfamily 1 group I member 2 ligand AGN-PC-07... 2 13
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3
5-hydroxytryptamine receptor 2B ligand SureCN1299053 family 1 1
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
D(2) dopamine receptor and D(4) dopamine receptor ligand 3-[1-... 1 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00386705 CHEMBL1950837 Bioactive 4-[[2-tert-butyl-5-(4,4,4-trifluorobutylsulfonyl)benzimidazol-1-yl]methyl]piperidine-1-carbaldehyde
CFAMM00386718 CHEMBL402281 Bioactive 2-cyclopropyl-5-ethylsulfonyl-1-(oxan-4-ylmethyl)benzimidazole
CFAMM00386731 CHEMBL257817 Bioactive 2-tert-butyl-5-(cyclopropylmethylsulfonyl)-1-(oxan-4-ylmethyl)benzimidazole
CFAMM00386744 CHEMBL1800163 Bioactive 1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-5-ethylsulfonylbenzimidazole
CFAMM00386737 CHEMBL1800168 Bioactive 2-tert-butyl-1-(cyclopropylmethyl)-5-ethylsulfonylbenzimidazole
CFAMM00386724 CHEMBL257612 Bioactive 3-[2-tert-butyl-1-(oxan-4-ylmethyl)benzimidazol-5-yl]sulfonylpropanenitrile
CFAMM00386750 CHEMBL404458 Bioactive 2-[2-tert-butyl-1-(oxan-4-ylmethyl)benzimidazol-5-yl]sulfonylethanol
CFAMM00386743 CHEMBL1950927 Bioactive 4-[[2-tert-butyl-5-(cyclopropylmethylsulfonyl)benzimidazol-1-yl]methyl]thiane 1,1-dioxide
CFAMM00386696 CHEMBL1950923 Bioactive 1-[4-[(2-tert-butyl-5-ethylsulfonylbenzimidazol-1-yl)methyl]piperidin-1-yl]ethanone
CFAMM00386710 CHEMBL1800175 Bioactive 1-(cyclopropylmethyl)-5-ethylsulfonyl-2-(1-methylcyclopentyl)benzimidazole
CFAMM00386723 CHEMBL404675 Bioactive 1-(cyclohexylmethyl)-5-ethylsulfonyl-2-propan-2-ylbenzimidazole
CFAMM00386716 CHEMBL403591 Bioactive 5-ethylsulfonyl-2-(2-methylpropyl)-1-(oxan-4-ylmethyl)benzimidazole
CFAMM00386729 CHEMBL401610 Bioactive 2-tert-butyl-1-(oxan-4-ylmethyl)-5-(4,4,4-trifluorobutylsulfonyl)benzimidazole
CFAMM00386742 CHEMBL1950926 Bioactive 1-[4-[[2-tert-butyl-5-(cyclopropylmethylsulfonyl)benzimidazol-1-yl]methyl]piperidin-1-yl]ethanone
CFAMM00386735 CHEMBL429134 Bioactive 2-tert-butyl-5-ethylsulfonyl-1-(oxan-4-ylmethyl)benzimidazole
CFAMM00386748 CHEMBL1800167 Bioactive 5-benzylsulfonyl-1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)benzimidazole
CFAMM00386741 CHEMBL1950928 Bioactive 1-[4-[(2-tert-butyl-5-cyclopentylsulfonylbenzimidazol-1-yl)methyl]piperidin-1-yl]ethanone
CFAMM00386694 CHEMBL1950925 Bioactive 4-[[2-tert-butyl-5-(cyclopropylmethylsulfonyl)benzimidazol-1-yl]methyl]piperidine-1-carbaldehyde
CFAMM00386747 CHEMBL1800166 Bioactive 2-[1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)benzimidazol-5-yl]sulfonyl-2-methylpropan-1-ol
CFAMM00386714 CHEMBL256316 Bioactive 2-[2-tert-butyl-1-(oxan-4-ylmethyl)benzimidazol-5-yl]sulfonylethanamine
CFAMM00386746 CHEMBL1800165 Bioactive 1-[1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)benzimidazol-5-yl]sulfonyl-2-methylpropan-2-ol
CFAMM00386720 CHEMBL1800655 Bioactive 5-tert-butylsulfonyl-1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)benzimidazole
CFAMM00386700 CHEMBL255519 Bioactive 5-(benzenesulfonyl)-2-tert-butyl-1-(cyclohexylmethyl)benzimidazole
CFAMM00386692 CHEMBL256534 Bioactive 2-tert-butyl-1-(cyclohexylmethyl)-5-ethylsulfonylbenzimidazole
CFAMM00386706 CHEMBL1800179 Bioactive 2-tert-butyl-5-ethylsulfonyl-1-[2-(trifluoromethoxy)ethyl]benzimidazole
CFAMM00386719 CHEMBL1800654 Bioactive 1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-5-propan-2-ylsulfonylbenzimidazole
CFAMM00386712 CHEMBL1950931 Bioactive 1-[4-[[2-tert-butyl-5-(4-fluorophenyl)sulfonylbenzimidazol-1-yl]methyl]piperidin-1-yl]ethanone
CFAMM00386725 CHEMBL257613 Bioactive 2-tert-butyl-1-(oxan-4-ylmethyl)-5-(3,3,3-trifluoropropylsulfonyl)benzimidazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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