CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8279
Family Name Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-methyl-3-(2-oxospiro[1H-indole-3,4'-thiane]-6-yl)benzamide family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00386850 Functional Category Bioactive
Superfamily Delta-type opioid receptor and Microsomal triglyceride transfer protein large subunit Binder Superfamily
Class Class 1365

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Serum albumin Inhibitor Ebselen Family 3 62
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Urokinase-type plasminogen activator Inhibitor 6-(n-phenylcarb... 2 11
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Progesterone receptor Ligand 3-(3,3-dimethyl-2-oxoindolin-5-yl... 2 10
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
Histone deacetylase 1 and Potassium voltage-gated channel subf... 4 36
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 7 1
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 3 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 6 5
Thyroid hormone receptor beta and Cellular tumor antigen p53 l... 1 4
Prelamin-A/C inhibitor CHEMBL1547148 family 1 8
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand 2-... 6 9
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Mitogen-activated protein kinase 14 inhibitor 4-chloro-N-cyclo... 2 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-3-... 2 0
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-0762XZ ... 3 1
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
Histone deacetylase 1 inhibitor SureCN3642893 family 10 23
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 10 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 3 5
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 3
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 3 0
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Mitogen-activated protein kinase 14 and Serine/threonine-prote... 1 1
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(1-hydroxy-3... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00386851 CHEMBL1825146 Bioactive N-cyclopropyl-3-fluoro-4-methyl-5-(1'-methylsulfonyl-2-oxospiro[1H-indole-3,4'-piperidine]-6-yl)benzamide
CFAMM00386850 CHEMBL1825149 Bioactive N-cyclopropyl-4-methyl-3-(2-oxospiro[1H-indole-3,4'-thiane]-6-yl)benzamide
CFAMM00386849 CHEMBL1800916 Bioactive N-cyclopropyl-3-fluoro-4-methyl-5-(2-oxospiro[1H-indole-3,1'-cyclopentane]-6-yl)benzamide
CFAMM00386848 CHEMBL1825150 Bioactive N-cyclopropyl-4-methyl-3-(1',1',2-trioxospiro[1H-indole-3,4'-thiane]-6-yl)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27266 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543