CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8280
Family Name Dihydrofolate reductase inhibitor 5-(3-phenoxypropoxy)-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamine;hydrochloride family
No. of Seeds 4 No. of Other Members 7
Family Centroid CFAMM00386861 Functional Category Bioactive
Superfamily Interleukin-12 subunit alpha and Interleukin-23 subunit alpha Inhibitor Ustekinumab Superfamily
Class Class 1147

Cousin Family NamesSeedsMembers
Dihydrofolate reductase inhibitor 10-[3-(4-chlorophenoxy)propo... 1 0
Dihydrofolate reductase inhibitor 4-[3-[(7,9-diamino-6,8,10-tr... 3 1
Dihydrofolate reductase inhibitor 1-[4-[3-[(7,9-diamino-6,8,10... 1 0


External ID

Functional Category

Molecule Name

CFAMM00386861 CHEMBL1800946 Bioactive 5-(3-phenoxypropoxy)-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamine;hydrochloride
CFAMM00386860 CHEMBL1801200 Bioactive 5-[3-(4-methoxyphenoxy)propoxy]-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamine;hydrochloride
CFAMM00386859 CHEMBL1801203 Bioactive 4-[3-[(2,4-diamino-1,3,5-triazaspiro[5.5]undeca-1,3-dien-5-yl)oxy]propoxy]benzenesulfonamide;hydrochloride
CFAMM00386852 CHEMBL1800937 Bioactive 10-(3-phenoxypropoxy)-6,8,10-triazaspiro[4.5]deca-6,8-diene-7,9-diamine;hydrochloride

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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