CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM829
Family Name Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 family
No. of Seeds 7 No. of Other Members 33
Family Centroid CFAMM00316346 Functional Category Bioactive
Superfamily Thrombopoietin receptor and Follicle-stimulating hormone receptor Binder Superfamily
Class Class 170

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Platelet-activating factor receptor ligand A-85783 family 13 62
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Insulin receptor and Tyrosine-protein kinase Lck ligand AGN-PC... 1 1
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 9 inhibitor AG... 3 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
Inosine-5'-monophosphate dehydrogenase and Nuclear receptor RO... 2 9
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Metabotropic glutamate receptor 1 ligand N-cyclohexyl-7-[[2-me... 2 0
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 2 2
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
Metabotropic glutamate receptor 5 ligand 5-methyl-N-(4-methyl-... 1 2
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 5 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
P2X purinoceptor 7 inhibitor SureCN110930 family 2 0
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Melanocortin receptor 4 ligand AGN-PC-076ANF family 1 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Metabotropic glutamate receptor 1 ligand SureCN8238239 family 3 0
Serine/threonine-protein kinase Chk1 inhibitor 2-(1,3-dihydroi... 2 5
Serine/threonine-protein kinase Chk1 inhibitor 2-indazol-1-yl-... 4 5
Orexin receptor type 2 and Orexin receptor type 1 ligand 6-ami... 3 1
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 5 3
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 6 1
Glucocorticoid receptor ligand 3-[1-(3-chloro-4-fluorophenyl)i... 2 0
Glucocorticoid receptor ligand 3-(1H-indol-5-yl)-2,2-dimethyl-... 2 7
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
MAP kinase-activated protein kinase 2 inhibitor 2-[(4,4-dimeth... 11 11
Thrombopoietin receptor ligand N-[4-[2-fluoro-3-(trifluorometh... 2 14
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Coagulation factor X inhibitor SureCN8290907 family 2 2
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 5 0
Receptor-type tyrosine-protein kinase FLT3 ligand SureCN74238 ... 6 0
Extracellular calcium-sensing receptor ligand 3-(1,3-benzothia... 5 1
Histone deacetylase 1 inhibitor SureCN1066177 family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00316288 CHEMBL1090357 Bioactive AGN-PC-07ZYOA
CFAMM00316346 CHEMBL1093234 Bioactive AGN-PC-07ZDR2
CFAMM00316287 CHEMBL1090356 Bioactive 3lzb
CFAMM00316285 CHEMBL1090350 Bioactive AGN-PC-07ZDR4
CFAMM00316291 CHEMBL1667943 Bioactive AGN-PC-09QIDO
CFAMM00316290 CHEMBL1090359 Bioactive AGN-PC-07ZDRD
CFAMM00316302 CHEMBL1090360 Bioactive Kinome_714

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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