CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8302
Family Name Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazol-1-yl)-2-fluorophenyl]ethyl]carbamoyl]cyclopropyl]pyridine-3-carboxamide family
No. of Seeds 10 No. of Other Members 0
Family Centroid CFAMM00386993 Functional Category Bioactive
Superfamily Cannabinoid receptor 1 and Cannabinoid receptor 2 Binder Superfamily 7
Class Class 4628

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 4
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Adenosine receptor A3 Ligand 2-phenyl-2h-pyrazolo[4,3-d]pyrimi... 2 7
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Prothrombin inhibitor SureCN5855286 family 15 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 3 59
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 34 4
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 3 1
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 2 1
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
Coagulation factor X inhibitor 2-(6-chloronaphthalen-2-yl)-5-m... 2 0
Coagulation factor X inhibitor SureCN8169809 family 12 18
Coagulation factor X inhibitor SureCN8165148 family 4 0
Coagulation factor X inhibitor AGN-PC-0749DA family 3 2
Coagulation factor X inhibitor AGN-PC-02WFR7 family 7 13
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-6-(1H-in... 2 3
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 4 0
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 7 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00386992 CHEMBL1801343 Bioactive N-[1-[[(1R)-1-[4-(3-chloroindazol-1-yl)-2-fluorophenyl]ethyl]carbamoyl]cyclopropyl]-6-methylpyridine-3-carboxamide
CFAMM00386998 CHEMBL1801354 Bioactive 6-chloro-N-[1-[[(1R)-1-[4-(3-chloroindazol-1-yl)-2-fluorophenyl]ethyl]carbamoyl]cyclopropyl]pyrazine-2-carboxamide
CFAMM00386991 CHEMBL1801344 Bioactive 6-bromo-N-[1-[[(1R)-1-[4-(3-chloroindazol-1-yl)-2-fluorophenyl]ethyl]carbamoyl]cyclopropyl]pyridine-3-carboxamide
CFAMM00386997 CHEMBL1801351 Bioactive N-[1-[[(1R)-1-[4-(3-chloroindazol-1-yl)-2-fluorophenyl]ethyl]carbamoyl]cyclopropyl]pyridazine-4-carboxamide
CFAMM00386990 CHEMBL1801345 Bioactive N-[1-[[(1R)-1-[4-(3-chloroindazol-1-yl)-2-fluorophenyl]ethyl]carbamoyl]cyclopropyl]-5-methylpyridine-3-carboxamide
CFAMM00386996 CHEMBL1801350 Bioactive 5-bromo-N-[1-[[(1R)-1-[4-(3-chloroindazol-1-yl)-2-fluorophenyl]ethyl]carbamoyl]cyclopropyl]pyridine-3-carboxamide
CFAMM00386995 CHEMBL1801348 Bioactive N-[1-[[(1R)-1-[4-(3-chloroindazol-1-yl)-2-fluorophenyl]ethyl]carbamoyl]cyclopropyl]-5-fluoropyridine-3-carboxamide
CFAMM00386994 CHEMBL1801349 Bioactive 5-chloro-N-[1-[[(1R)-1-[4-(3-chloroindazol-1-yl)-2-fluorophenyl]ethyl]carbamoyl]cyclopropyl]pyridine-3-carboxamide
CFAMM00386993 CHEMBL1801342 Bioactive N-[1-[[(1R)-1-[4-(3-chloroindazol-1-yl)-2-fluorophenyl]ethyl]carbamoyl]cyclopropyl]pyridine-3-carboxamide
CFAMM00387000 CHEMBL1801352 Bioactive N-[1-[[(1R)-1-[4-(3-chloroindazol-1-yl)-2-fluorophenyl]ethyl]carbamoyl]cyclopropyl]pyrimidine-5-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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